基于肠道微生态探讨中药治疗放射性肠炎研究进展

Research progress of TCM in treating radiation enteritis based on intestinal microecology

放射性肠炎患者普遍存在肠道微生态失衡情况。中药调整肠道微生物菌群具有一定优势,临床多从热毒伤络证、寒热错杂证、脾虚湿滞证、脾肾阳虚证、阴虚津亏证辨证论治本病,主要运用白头翁汤、乌梅丸、四君子汤等方剂加减治疗,可通过改善肠道菌群丰度、抑制炎性细胞因子水平、发挥类益生元功效及免疫调节作用等促进肠道微生态的平衡,从而治疗放射性肠炎等消化系统疾病。

Patients with radioactive enteritis generally have certain intestinal microecological imbalance.Traditional Chinese Medicine(TCM)has showed good advantage in regulating intestinal microbial flora.In clinical practice,patients are treated based on syndrome differentiation of heat toxin damaging collaterals,cold-heat mixed syndrome,spleen deficiency and dampness stagnation,spleen and kidney yang deficiency,yin deficiency and body fluid deficiency.The Baitouweng Decoction,Wumei Pill,Sijunzi Decoction are the common prescriptions.TCM can promote the balance of intestinal microecology and treat digestive diseases such as radioactive enteritis,by improving the abundance of intestinal flora,inhibiting the level of inflammatory cytokines,and playing the role of probiotics and immune regulation.