髓鞘少突胶质细胞糖蛋白抗体阳性视神经炎合并抗N-甲基-D-天冬氨酸受体脑炎1例

Myelin oligodendrocyte glycoprotein antibody positive optic neuritis with anti-N-methyl-D-aspartate receptor encephalitis: a case report

1例主诉为双眼视力下降伴眼球转动痛1周的6岁女性患儿就诊眼科。病程中出现不爱交流、语言倒退、发音困难、饮水和进食呛咳等症状,血清髓鞘少突胶质细胞糖蛋白(MOG)抗体、血清及脑脊液抗N-甲基-D-天冬氨酸受体(NMDAR)抗体阳性。诊断:(1)双眼MOG抗体相关性视神经炎;(2)抗NMDAR脑炎。入院后给予糖皮质激素冲击治疗,随访15个月病情稳定,未复发。

A 6-year-old girl had binocular vision loss with pain for one week.The patient presented with symptoms such as non-communication,language deterioration,dysphonia,and choking when drinking and eating during the course.The serum myelin oligodendrocyte glycoprotein antibody was positive.Both the serum and cerebrospinal fluid anti-N-methyl-D-aspartate receptor antibody were also positive.The diagnoses were myelin oligodendrocyte glycoprotein antibody positive optic neuritis and anti-N-methyl-D-aspartate receptor encephalitis.High-dose intravenous glucocorticoids were given.Recurrence was not observed during the 15-month clinical follow-up.