摘要
A large-scale vaccination of coronavirus disease-19(COVID-19)in adults has been conducted for nearly a year,and there is a growing recognition that immunization for children is also essential.It has been months since emergency use of pediatric COVID-19 vaccine was approved,we reviewed the prevalence and transmission of COVID-19 in children.The prevalence of COVID-19 in children is reduced due to vaccination even in a Delta prevalent period,so an increase in the vaccination rate is needed in children.Although the precise role of children in the transmission requires more research to uncover,they likely played a significant role,according to the available literature.We also described four candidate COVID-19 vaccines for children on their safety and immunogenicity and the impact of severe acute respiratory syndrome coronavirus 2 variants on childhood vaccination.Safety issues on pediatric vaccines post-approval,like adverse events following immunization and adverse events of special interest require studies on long-term and effective regulatory mechanisms.
