清胃舒颗粒治疗肝胃郁热型难治性胃食管反流病的疗效及对复发率的影响

Efficacy Evaluation of Qingweishu Granule in Treating Refractory Gastroesophageal Reflux Disease with Liver and Stomach Heat Stasis and Its Influence on Recurrence Rate

目的 观察清胃舒颗粒联合雷贝拉唑肠溶胶囊、莫沙必利分散片治疗肝胃郁热型难治性胃食管反流病(Gastroesophageal reflux disease,GERD)的临床疗效及对复发率的影响。方法 将100例肝胃郁热型难治性GERD患者随机分为治疗组和对照组,每组50例。对照组予雷贝拉唑肠溶胶囊、莫沙必利分散片口服,连续治疗8周。治疗组在对照组的基础上加清胃舒颗粒口服。观察2组治疗前、治疗8周后临床疗效的差异;比较2组抑郁、焦虑及生存质量评定的变化;随访半年,对比复发率的差异。结果 与治疗前比较,2组患者治疗后临床疗效、SDS评分、SAS评分及SF-36评分均得以改善;治疗组患者中临床疗效、SDS评分、SAS评分及SF-36评分改善明显大于对照组,且复发率明显小于对照组,差异有统计学意义(P<0.05)。结论 清胃舒颗粒联合雷贝拉唑肠溶胶囊、莫沙必利分散片治疗肝胃郁热型难治性GERD疗效确切,且改善患者精神心理状态,有效降低疾病复发率。

Objective To observe the clinical effect of Qingweishu granules combined with rabeprazole enteric-soluble capsule and mosapride dispersible tablet in the treatment of gastroesophageal reflux disease(GERD) and the influence on the recurrence rate. Methods 100 cases of refractory GERD with liver and stomach heat stasis were randomly divided into treatment group and control group,with 50 cases in each group.The control group was given rabeprazole enteric-coated capsules and mosapride dispersible tablets for 8 weeks. The treatment group was added Qingweishu granule orally on the basis of the control group. The difference of clinical efficacy between the two groups before treatment and 8weeks after treatment was observed. The changes of depression,anxiety and quality of life were compared between the two groups. The patients were followed up for half a year to compare the difference in recurrence rate. Results Compared with before treatment,clinical efficacy,SDS score,SAS score and SF-36 score were improved in 2 groups after treatment. The improvement of clinical efficacy,SDS score,SAS score and SF-36 score in the treatment group was significantly higher than that in the control group(P< 0. 05),and the recurrence rate was significantly lower than that in the control group(P< 0. 05). The difference was statistically significant(P< 0. 05). Conclusion Qingweishu granules combined with rabeprazole enteric-soluble capsules and moxapride dispersible tablets have an effective effect in the treatment of refractory GERD with liver and stomach heat stagnation,and improve the mental state of patients,effectively reduce the recurrence rate of the disease.