一种氨甲基异喹啉化合物的合成

Synthesis of an Aminomethyl Isoquinoline Chemical Compound

以4-溴苯甲醛为起始原料,与氨基乙醛缩二甲醇反应,产物还原后在P_(2)O_(5)/浓H_(2)SO_(4)作用下得到6-溴异喹啉,与CuCN/CuI作用得到6-氰基异喹啉,经酸性水解、成酯、还原得到异喹啉-6-甲醇,与邻苯二甲酰亚胺反应,再与水合肼作用得到6-氨甲基异喹啉。通过核磁共振氢谱^(1)H NMR和API-MS确定了化学结构。

The synthesis began with reaction of 4-bromobenzaldehyde and aminoacetaldehyde dimethyl acetal,followed by reduction and treatment of P_(2)O_(5)/conc.H_(2)SO_(4) to give 6-bromoisoquinoline,which was then treated by CuCN/CuI.The resulting 6-cyanisoquinoline went through acidic hydrolysis,esterification,and reduction,generating isoquinoline-6-ol.Treatment with phthalimide and N_(2)H_(4)·H_(2)O produced 6-aminomethylisoquinoline.The product was characterized by ^(1)H NMR,and API-MS.