胞外囊泡对改善子宫内膜容受性的作用与研究现状

Effect of extracellular vesicles on improving en⁃dometrial receptivity and the research status.

子宫内膜容受性是影响胚胎顺利植入的关键因素,子宫内膜容受性异常将导致胚胎着床失败和胎盘发育异常。胚胎植入过程中,母体和胚胎的胞外囊泡的有序产生和精确协调确保了胚胎的顺利植入。间充质干细胞来源的胞外囊泡可改善病理状态下的子宫内膜容受性。

Endometrial receptivity is the key factor affecting embryo implantation.Abnormal endometrial receptivity leads to embryo implantation failure and abnormal placental development.In the process of embryo implantation,the orderly generation and pre⁃cise coordination of extracellular vesicles between the maternal tissues and the embryo ensure the smooth embryo implantation.The extracellular vesicles derived from mesenchymal stem cells can improve the impaired endometrial receptivity.