自体造血干细胞移植治疗霍奇金淋巴瘤38例临床疗效及预后影响因素分析

Clinical Efficacy and Prognostic Factors of Autologous Hematopoietic Stem Cell Transplantation for Hodgkin’s Lymphoma in 38 Cases

目的探讨自体造血干细胞移植(ASCT)治疗霍奇金淋巴瘤(HL)的临床疗效以及影响预后的因素。方法回顾2007年10月至2021年10月于郑州大学附属肿瘤医院经ASCT治疗的HL38例患者资料,Kaplan-Meier和Cox方法分析移植后疗效以及预后影响因素。结果38例移植患者均获得造血重建。全组患者移植前后CR率分别为55.3%和81.6%,5年PFS和OS分别为76.1%和79.0%。单因素分析显示B症状、IPS评分、移植前缓解状态、结外受累和预处理方案(均P<0.05)是影响HL患者ASCT预后的因素,多因素分析显示B症状(P<0.05)是影响5年PFS的独立危险因素。结论ASCT治疗高危、复发难治HL患者的疗效显著,有B症状是影响移植预后的独立危险因素。

Objective To investigate the clinical efficacy and prognostic factors of autologous hematopoietic stem cell transplantation(ASCT)for Hodgkin’s lymphoma(HL).Methods We retrospectively analyzed the data of 38 patients with HL who underwent ASCT.Kaplan-Meier and Cox methods were used to analyze the curative effect and prognostic factors after transplantation.Results All 38 transplanted patients obtained hematopoietic reconstitution.The CR rates before and after transplantation were 55.3% and 81.6%,respectively,and the 5-year PFS and OS were 76.1% and 79.0%,respectively.Univariate analysis showed that B symptoms,IPS score,pre-transplant remission status,extranodal invasion,and pretreatment regimen were the factors affecting the prognosis of ASCT in patients with HL.Multivariate analysis showed that B symptom was an independent risk factor affecting 5-year PFS.Conclusion ASCT is effective in the treatment of high-risk,relapsed,and refractory patients with HL.B symptom is an independent risk factor affecting the prognosis of transplantation.