DNA甲基化影响鼻咽癌侵袭转移相关信号通路的研究进展

Research Progress on Influence of DNA Methylation on Signal Pathways Related to Invasion and Metastasis of Nasopharyngeal Carcinoma

鼻咽癌(NPC)是头颈部最常见的恶性肿瘤之一,具有发病隐匿、侵袭性强及易早期发生淋巴结转移等特点。多种信号通路在鼻咽癌的侵袭与转移中发挥作用,然而其具体机制尚未完全阐明。最近研究发现,鼻咽癌相关基因DNA甲基化可以通过多种信号通路影响鼻咽癌的侵袭与转移,其中主要包括Wnt/β-catenin、PI3K/AKT及MAPK等信号通路。本文围绕DNA甲基化通过上述不同信号通路影响鼻咽癌侵袭与转移的具体作用机制进行综述。

Nasopharyngeal carcinoma(NPC)is one of the most common malignant tumors of the head and neck region.NPC has the characteristics of insidious onset,strong invasiveness and early lymph node metastasis.A variety of signaling pathways play a role in the invasion and metastasis of nasopharyngeal carcinoma,but the specific mechanism has not yet been fully elucidated.Recent studies have found that DNA methylation of nasopharyngeal carcinoma-related genes can affect the invasion and metastasis of nasopharyngeal carcinoma through a variety of signaling pathways including Wnt/β-catenin,PI3K/AKT and MAPK signaling pathways.This article reviews the specific mechanism of DNA methylation affecting the invasion and metastasis of nasopharyngeal carcinoma through the above-mentioned signaling pathways.