胚胎植入的相关信号通路

The Signaling Pathways Involved in Embryo Implantation

胚胎植入及胎儿发育是母胎相互识别、相互适应的过程,该过程蕴含复杂的分子机制,至今尚未阐明。胚胎植入失败是不明原因性不孕、早期流产和反复种植失败的重要原因之一。胚胎植入与子宫内膜容受性密切相关,胚胎植入过程中机体分泌的各种细胞因子可以调控子宫内膜容受性,有效改善妊娠结局。目前研究已发现Notch、Janus激酶-信号转导及转录活化因子、Wnt/β-连环蛋白、丝裂原活化蛋白激酶和核因子κB等信号通路与胚胎植入息息相关。综述这些胚胎植入相关的信号通路及其研究进展,探讨胚胎着床机制,并为改善妊娠结局提供理论依据。

Embryo implantation and fetal development are the process of mutual recognition and adaptation of mother and fetus. The molecular mechanisms of this process are complex. However, the exact mechanisms have not yet been elucidated. Implantation failure is one of the important causes of unexplained infertility, early miscarriage and repeated implantation failure. Embryo implantation is closely related to endometrial receptivity, and various cytokines secreted during implantation can regulate endometrial receptivity and effectively improve pregnancy outcomes. Current studies have found that the Notch, Janus kinase-signal transducer and activator of transcription, Wnt/β-catenin, mitogen activated protein kinase, nuclear factor κB and other signals are involved in embryo implantation. We review the research progress of the signaling pathways involved in embryo implantation, as a reference for exploring the mechanism of embryo implantation and improving pregnancy outcome.