参芪扶正注射液辅助化疗对晚期胃癌患者化疗敏感性及T淋巴细胞亚群的影响

Effects of Shenqi Fuzheng Injection on Chemotherapy Sensitivity and T Lymphocyte Subsets in Patients with Advanced Gastric Cancer

目的探究参芪扶正注射液辅助化疗对晚期胃癌患者化疗敏感性及血清肿瘤标志物、炎性因子、凋亡相关因子、T淋巴细胞亚群的影响。方法选取2020年8月—2021年8月收治的晚期胃癌86例,根据治疗方法分为观察组和对照组,分别给予参芪扶正注射液辅助FOLFOX6方案(奥沙利铂、亚叶酸钙、5-氟尿嘧啶)和单纯FOLFOX6方案治疗,均连续治疗3个周期。比较2组细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、组织多肽特异性抗原(TPS)、癌抗原125(CA125)、肿瘤坏死因子-α(TNF-α)、可溶性白细胞介素-2受体(sIL-2R)、白细胞介素-6(IL-6)、B细胞淋巴瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)及T淋巴细胞亚群CD3+、CD4+和CD4+/CD8+值及近期疗效。结果治疗后,2组血清CYFRA21-1、NSE、TPS、CA125、TNF-α、sIL-2R、IL-6水平均较治疗前明显下降,且观察组均明显低于对照组(P<0.05)。治疗后,2组Bcl-2积分光密度值均较治疗前明显下降,且观察组明显低于对照组(P<0.05);治疗后,2组Bax积分光密度值均较治疗前明显升高,且观察组明显高于对照组(P<0.05)。治疗后,观察组CD3+、CD4+和CD4+/CD8+值均较治疗前明显升高,而对照组均较治疗前明显下降,且观察组均明显高于对照组(P<0.05)。观察组临床总有效率明显高于对照组(P<0.05)。结论参芪扶正注射液辅助FOLFOX6方案可降低晚期胃癌患者肿瘤标志物和炎性因子水平,提高外周血T淋巴细胞亚群水平,改善凋亡相关因子表达,增强化疗敏感性,提高近期疗效。

Objective To explore the effect of Shenqi Fuzheng injection adjuvant chemotherapy for patients with advanced gastric cancer on chemotherapy sensitivity,serum tumor markers,inflammatory factors,apoptosis-related factors and T lymphocyte subsets.Methods A total of 86 patients with advanced gastric cancer who were treated in our hospital from August 2020 to August 2021 were selected and divided into observation group and control group according to different treatment methods.They were given Shenqi Fuzheng injection supplemented with FOLFOX6 regimen(oxaliplatin,leucovorin,5-fluorouracil)and FOLFOX6 regimen alone respectively for 3 consecutive cycles.Comparison of cytokeratin 19 fragment(CYFRA21-1),neuron-specific enolase(NSE),tissue polypeptide-specific antigen(TPS),cancer antigen-125(CA-125),tumor necrosis factor-α(TNF-α),soluble interleukin-2 receptor(sIL-2 R),interleukin-6(IL-6),B-cell lymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax),T lymphocyte subsets CD3+,CD4+and CD4+/CD8+value and short-term efficacy was performed between the two groups.Results After treatment,the serum levels of CYFRA21-1,NSE,TPS,CA-125,TNF-α,sIL-2 R and IL-6 in the two groups were significantly lower than those before treatment,and significantly lower in the observation group than in the control group(P<0.05).After treatment,the Bcl-2 integral optical density values in both groups were significantly decreased compared with those before treatment,which were significantly lower in the observation group than in the control group(P<0.05).After treatment,the Bax integral optical density values in both groups were significantly increased compared with those before treatment,which were significantly higher in the observation group than in the control group(P<0.05).After treatment,the CD3+,CD4+and CD4+/CD8+value in the observation group were significantly higher than those before treatment,which were significantly lower in the control group than those before treatment,and significantly higher in the observation group than in the control group(P<0.05).The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Shenqi Fuzheng injection assisted by FOLFOX6 regimen can reduce the levels of tumor markers and inflammatory factors in patients with advanced gastric cancer,increase the levels of peripheral blood T lymphocyte subsets,improve the expression of apoptosis-related factors,enhance chemotherapy sensitivity,and improve short-term efficacy.