湿润烧伤膏联合自体富血小板凝胶序贯治疗Ⅲ~Ⅳ期感染性压疮疗效分析

Clinical Efficacy of the Sequential Application of MEBO and Autologous Platelet-rich Gel in the Treatment of Stage Ⅲ-Ⅳ Pressure Ulcer

目的 分析探讨湿润烧伤膏联合自体富血小板凝胶序贯治疗Ⅲ~Ⅳ期感染性压疮的临床效果。方法选取2015年6月至2020年6月湘潭市第二人民医院收治的69例Ⅲ~Ⅳ期感染性压疮患者作为研究对象,按照治疗方法将其分为研究组(35例)与对照组(34例),研究组患者采用湿润烧伤膏联合自体富血小板凝胶序贯治疗,对照组患者采用凡士林油纱联合自体富血小板凝胶序贯治疗,对比观察两组患者治疗至创面无菌时间、压疮愈合计分量表(PUSH)评分情况。结果 研究组患者中治疗至创面无菌时间<2周者25例、2~4周者8例、>4周者2例,明显优于对照组患者的治疗至创面无菌时间<2周者6例、2~4周者20例、>4周者8例(Z=-4.349,P<0.001)。治疗4、6、8周时,研究组患者的PUSH评分均明显低于对照组(t=8.340、6.792、8.144,P均<0.001)。结论 湿润烧伤膏联合自体富血小板凝胶序贯治疗Ⅲ~Ⅳ期感染性压疮,可有效控制创面感染,促进创面愈合,疗效显著,临床应用价值较高。

Objective To analyze the clinical Efficacy of MEBO combined with autologous platelet-rich gel in treating stage Ⅲ-Ⅳ pressure ulcer.Methods 69 patients with stage Ⅲ-Ⅳ pressure ulcer,admitted into Xiangtan Second People’s Hospital between June 2015 and June 2020,were enrolled as research subjects,and divided into study group(n=35) and control group(n=34) based on the different treatments they received.Patients in study group were treated with MEBO and autologous platelet-rich gel sequentially,while patients were treated with Vaseline gauze and autologous platelet-rich gel sequentially in control group.Time from treatment start to wound germ free and scores of pressure ulcer scale for healing(PUSH) were compared between the two groups.Results The time from treatment start to wound germ free was <2 weeks in 25 cases,2-4 weeks in 8 cases and> 4 weeks in 2 cases in study group,being obviously better than control group(Z=-4.349,P <0.001)-<2 weeks in 6 cases,2-4 weeks in 20 cases and>4 weeks in 8 cases.At week 4,6 and 8 of treatment,the PUSH scores of patients were significantly lower in study group compared with control group(t=8.340,6.792 and 8.144,all P <0.001).Conclusion The sequential application of MEBO and autologous platelet-rich gel in the treatment of stage Ⅲ-Ⅳ pressure ulcer can effectively control wound infection,promote wound healing,and realize definite clinical efficacy.