摘要
外被体蛋白复合物β'亚基(COPB2)是外被体蛋白复合物(COPI)的组成亚基之一,具有色氨酸-天冬氨酸(WD)重复序列,其与信号转导、细胞周期的调节和细胞凋亡相关。COPB2在人类多种肿瘤中异常表达,且与临床病理特征密切相关,通过多种机制调节细胞增殖、凋亡、侵袭等生物学功能,可作为肿瘤生物标志物和治疗靶点。本文就COPB2在肿瘤发生、发展中的生物学功能、主要的相关机制和潜在临床意义作一综述。
The coatomer protein complex subunit beta 2(COPB2)is one of the component subunits of the coatomer complex I(COPI),and has a tryptophan-aspartic(WD)repeat sequence,which is associated with signal transduction,regulation of the cell cycle and apoptosis.COPB2 is aberrantly expressed in a variety of human tumors and is closely related to clinicopathological features.It regulates cell proliferation,apoptosis,invasion and other biological functions through various mechanisms,and can be used as a tumor biomarker and therapeutic target.This article reviews the biological function,main related mechanism and potential clinical significance of COPB2 in tumorigenesis and development.
作者
吴彪
郭显林
张素青
WU Biao;GUO Xianlin;ZHANG Suqing(Hepatopancreatobiliary Surgery Department,Cancer Hospital Affiliated to Nantong University,Jiangsu Nantong 226361,China)
出处
《现代肿瘤医学》
CAS
北大核心
2022年第19期3629-3633,共5页
Journal of Modern Oncology
基金
江苏省南通市卫生科学技术奖励项目(编号:学科09)
江苏省南通市“226高层次人才培养工程”项目(编号:YYRC1713)。
关键词
COPB2
肿瘤
增殖
凋亡
COPB2
tumour
proliferation
apoptosis
