黄嘌呤氧化酶抑制剂的研究进展

Research progress of xanthine oxidase inhibitors

黄嘌呤氧化还原酶(xanthine oxidoreductase,XOD)是一种高度通用的黄素酶,在不同物种之间以及生物各种组织中普遍存在。痛风是由于体内尿酸代谢障碍,导致尿酸水平过高,影响机体的正常运行。抑制黄嘌呤氧化还原酶可以降低尿酸水平,发挥抗高尿酸的作用。现如今临床上用于治疗痛风、高尿酸血症最有效的药物还是黄嘌呤氧化还原酶抑制剂。本文归纳了黄嘌呤氧化还原酶抑制剂的药理作用和临床应用,并对近年来已经上市和处于开发阶段的黄嘌呤氧化还原酶抑制剂进行总结,综述了黄嘌呤氧化还原酶抑制剂的最新进展。

Xanthine oxidoreductase(XOD)is a highly versatile flavin enzymes,which is ubiquitous in different species and tissues.Gout is due to the metabolic disorder of uric acid in the body,which leads to the high level of uric acid and affects the normal operation of the body.Inhibition of XOD can reduce the level of uric acid and play the role of anti hyperuricemia.Nowadays,the most effective drug for the treatment of gout and hyperuricemia is XOD inhibitor.This paper summarized the pharmacological effects and clinical applications of XOD inhibitors,and summarized the XOD inhibitors that have been on the market and in the development stage in recent years,and reviewed the latest progress of XOD inhibitors.