加巴喷丁在血液透析患者治疗中的应用

Application of gabapentin in the treatment of hemodialysis patients

随着我国尿毒症患病率及生存时长增加,血液透析人才的相对短缺造成基层技术相对的缺乏,由于国内各地医疗保障报销政策的差异性,导致部分地区高通量透析、血液灌流、高价值药物等辅助治疗手段难以推广,很多患者透析充分性难以达标,血液透析并发症不能及时得到有效的治疗。目前,针对这些并发症的各种治疗方法中,加巴喷丁(gabapentin,GBP)的综合优势更强一些,为此我们搜索了电子数据库(PubMed、中国知网)近几年关于GBP在血液透析方面治疗的相关文章,分为尿毒症瘙痒症(uremia pruritus,UP)、不宁腿综合征(restless legs syndrome,RLS)、尿毒症性周围神经痛三个方面阐述。该文尽可能给血液透析从业人员提供一些GBP在血液透析并发症治疗思路。

With the higher prevalence and the longer survival of uremia patients in our country,the shortage of hemodialysis professionals prevails and accounts for the insufficiency of hemodialysis technologies in basic communities.The advanced assistant dialysis measures,such as high flux hemodialysis,hemoperfusion and drugs of expensive prices,are hardly to be adopted in several areas due to the different health insurance policies,causing dialysis inadequacy and hemodialysis complications in many patients in these areas.Gabapentin(GBP)has a better therapeutic effect in the treatment of many hemodialysis complications.We therefore searched the databases of PubMed and CNKI for the studies in recent years about GBP in the treatment of hemodialysis complications,including uremic pruritus,restless legs syndrome and uremic peripheral neuralgia.In this paper,we try to provide the therapeutic strategies against hemodialysis complications by using GBP for hemodialysis professionals.