尿毒症毒素与慢性肾脏病肌少症的关系研究进展

Research progress in the relationship between uremic toxins and sarcopenia in chronic kidney disease patients

慢性肾脏病(chronic kidney disease,CKD)肌少症有多种病因,尿毒症毒素是其病因之一,且是CKD肌少症有别于其他肌少症的因素。对尿毒症毒素影响肌少症的文献进行汇总分析,一方面了解其发病机制,另一方面为CKD肌少症的治疗提供一定的参考。文章侧重对尿毒症毒素与CKD肌少症关系的研究进展进行综述,试图阐述从毒素清除方面治疗CKD肌少症也是非常有意义的研究方向,可能会发现治疗CKD肌少症的新策略。

Sarcopenia in chronic kidney disease patients is caused by many factors,of which one is the uremic toxins,which distinguishes CKD sarcopenia from other sarcopenias.We have reviewed and analyzed the literature about the effect of uremic toxins on sarcopenia in order to comprehend the pathogenesis of sarcopenia and to find out the references for the treatment strategies of sarcopenia in CKD patients.Here we summarized the recent progresses in the relationship between uremic toxins and CKD sarcopenia,in an attempt to explore a meaningful research subject and a novel strategy for the treatment of CKD sarcopenia by removal of uremic toxins.