机械压应力对成骨细胞分化增殖和碱性磷酸酶的影响

Effect of compressive stress on differentiation and proliferation of osteoblasts

成骨细胞负责机体骨基质合成、分泌以及矿化,是骨形成主要的功能细胞。碱性磷酸酶是成骨细胞的一种标志物,直接反应成骨细胞功能和活性。成骨细胞处于机体内复杂的力学环境中,在以机械压应力为主的各种力学刺激下不断增殖分化。因此,探索对成骨细胞加载合适的机械压应力刺激以促进骨骼重建,成为治疗骨缺损、骨折延迟愈合等临床问题的新方向。本研究梳理机械压应力刺激对成骨细胞分化增殖和碱性磷酸酶影响的最新研究成果,总结不同的机械压应力加载模式和潜在的分子作用机制,以期为后续相关的基础研究提供便利,进而服务于临床。

Osteoblasts are responsible for the synthesis,secretion and mineralization of bone matrix,and are the main functional cells for bone formation.Alkaline phosphatase is a marker of osteoblasts,which directly reflects the function and activity of osteoblasts.Osteoblasts exist in a complex mechanical environment in the body and constantly proliferate and differentiate under various mechanical stimuli,mainly mechanical compressive stress.Therefore,it is a new direction for the treatment of bone defects,delayed fracture healing and other clinical problems,so as to explore the appropriate mechanical compressive stress stimulation to osteoblasts to promote bone reconstruction.This paper reviewed the latest research results on the effects of mechanical compressive stress stimulation to osteoblast differentiation and proliferation and alkaline phosphatase,summarized different mechanical compressive stress loading modes and potential molecular mechanisms,with a view to providing convenient reference for subsequent related basic research and further serving clinical problems.