乳腺癌磁共振成像影像表现与糖类抗原153、癌胚抗原、铁蛋白的相关性研究

Study on the Correlation between Magnetic Resonance Imaging Findings andCarbohydrate Antigen 153, Carcinoembryonic Antigen and Ferritinin Patients with Breast Cancer

目的:探讨乳腺癌患者磁共振成像(MRI)影像表现与糖类抗原153(CA153)、癌胚抗原(CEA)、铁蛋白的相关性。方法:收集2018年1月-2022年3月于中国人民解放军联勤保障部队第九〇一医院经手术病理证实为乳腺癌的患者48例作为研究组,其中临床分期I期15例,II期19例,III期6例,IV期8例。另选取同时期经手术确诊为乳腺良性病变的患者36例作为对照组。分析比较研究组和对照组血清CA153、CEA、铁蛋白含量及不同临床分期乳腺癌患者血清CA153、CEA、铁蛋白含量的差异。采用Pearson分析乳腺癌患者MRI影像学表现与血清CA153、CEA、铁蛋白含量的相关性。结果:研究组血清CA153、CEA、铁蛋白含量均显著高于对照组,差异有统计学意义(P<0.001);III-IV期乳腺癌患者血清CA153、CEA、铁蛋白含量均显著高于I-II期,差异有统计学意义(P<0.001)。经Pearson相关性分析显示,肿瘤直径越大和有淋巴结转移时,血清CA153、CEA、铁蛋白含量越高,即乳腺癌患者肿瘤直径和淋巴结转移与血清CA153、CEA、铁蛋白含量呈正相关性(P<0.05);而乳腺癌患者病灶类型、肿瘤形态、肿瘤边缘、强化特征和时间-信号强度曲线与血清CA153、CEA、铁蛋白含量无相关性(P>0.05)。结论:乳腺癌患者血清CA153、CEA、铁蛋白的含量与临床分期相关,同时与MRI影像检查发现的肿瘤直径和淋巴结转移具有一定相关性。

Objective:To investigate the correlation between magnetic resonance imaging(MRI)findings and carbohydrate antigen 153(CA153),carcinoembryonic antigen(CEA)and ferritin in patients with breast cancer.Methods:A total of 48 patients with breast cancer confirmed by surgery and pathology in the 901st Hospital of Joint Logistics Support Force of PLA from January 2018 to March 2022 were collected as the study group,including 15 patients with clinical stage I,19 patients with stage II,6 patients with stage III and 8 patients with stage IV.Another 36 patients with benign breast lesions were selected as the control group.The serum CA153,CEA and ferritin contents in the study group and the control group were compared,and the serum CA153,CEA and ferritin contents in patients with different clinical stages of breast cancer were analyzed and compared.Pearson was used to analyze the correlation between MRI findings and serum CA153,CEA and ferritin contents in patients with breast cancer.Results:The serum CA153,CEA and ferritin contents in the study group were significantly higher than those in the control group(P<0.001);The serum CA153,CEA and ferritin contents in patients with stage III-IV breast cancer were significantly higher than those in stage I-II patients(P<0.001).Pearson correlation analysis showed that the larger the tumor diameter and lymph node metastasis were,the higher the serum CA153,CEA and ferritin contents were in patients with breast cancer.That is the tumor diameter and lymph node metastasis were positively correlated with the serum CA153,CEA and ferritin contents in patients with breast cancer(P<0.05);There was no correlation between the lesion type,tumor shape,tumor margin,enhancement characteristics and time-signal intensity curve and the serum CA153,CEA and ferritin contents in patients with breast cancer(P>0.05).Conclusion:The serum CA153,CEA and ferritin contents in patients with breast cancer were correlated with clinical stage,and also with tumor diameter and lymph node metastasis detected by MRI.