ACE2-Ang-(1-7)-MasR轴与中枢神经系统疾病关系研究进展

Research progress on the relationship between ACE2-Ang-(1-7)-MasR axis and central nervous system diseases

肾素-血管紧张素系统(RAS)具有维持心血管稳态、水电解质平衡的作用,这一过程中血管紧张素转化酶Ⅱ(ACE2)及其作用轴血管紧张素1-7[Ang-(1-7)]和Mas受体(MasR)共同组成的ACE2-Ang-(1-7)-MasR轴广泛参与中枢神经系统疾病的病理生理学过程。本文总结RAS结构与功能以及ACE2-Ang-(1-7)-MasR轴在缺血性卒中、认知功能障碍、焦虑状态、神经系统变性疾病发病机制中的作用进展,以期提高研究人员和临床医师对ACE2-Ang-(1-7)-MasR轴的认识,为药物研发提供新靶点。

Renin-angiotensin system(RAS) plays an important role in maintaining cardiovascular homeostasis,water and electrolyte balance in the body,and angiotensin converting enzyme Ⅱ(ACE2) and its axis of action angiotensin-(1-7) [Ang-(1-7)] and Mas receptor(MasR) composed of Ang-(1-7) and MasR axis can play an important role in this process,it can widely participate in the pathophysiological process of central nervous system diseases.Based on the structure and function of RAS,this study plans to sort out the latest relevant research results on the role of ACE2-Ang-(1-7)-MasR axis in ischemic stroke,cognitive dysfunction,anxiety state and neurodegenerative disease,improve the understanding of researchers and clinicians,and provide ideas for the development of new targets for central nervous system disease drugs in the future.