层状双金属氢氧化物在肿瘤诊疗中的研究进展

Research Progress of Layered Double Hydroxides in Tumor Diagnosis and Therapy

纳米医学的发展拓展了生物医学的研究范畴,尤其是在肿瘤的精准诊疗领域担当了重要角色。在各种纳米材料中,层状双金属氢氧化物(layered double hydroxides, LDH)是一种典型的二维纳米材料,具有良好的生物相容性和胶体稳定性、较大的荷载量、易功能化修饰等优点,在肿瘤的诊疗领域受到研究者们的广泛关注。近年来,越来越多结构精巧、性能优良、副作用小的LDH基纳米平台在这一领域被报道。介绍了LDH纳米颗粒的结构与性质,总结了LDH基纳米平台的构建策略,概述了近5年LDH基纳米平台在肿瘤诊疗领域的最新进展,最后还讨论了LDH基纳米平台向临床医学及精准治疗应用的挑战和未来发展策略,希望能够引起研究者对LDH基纳米平台在肿瘤诊疗领域更广泛的研究兴趣。

The development of nanomedicine has expanded the research boundary of biomedicine, especially in the field of precision tumor diagnosis and therapy. Among various nanomaterials, layered double hydroxides(LDH), a typical two-dimensional nanomaterial with good biocompatibility and colloidal stability, large loading capacity, easy functional modification, has attracted extensive attention of researchers in the field of tumor theranostics. In recent years, more and more LDH-based nanoplatforms with exquisite structure, excellent performance and low side effects have been reported in this field. This review introduces the structure and properties of LDH nanoparticles, summarizes the construction strategies of LDH-based nanoplatforms, and summarizes the latest progress of LDH-based nanoplatforms in tumor diagnosis and treatment in the past five years. The challenges and future development strategies for LDH-based nanomedicines toward clinical medicine and precision therapy applications are also discussed. It is hoped that this review will arouse researchers’ wide interest in LDH-based nanoplatforms in the field of tumor theranostics.