黄芪甲苷Ⅳ防治心力衰竭作用

Astragaloside Ⅳ in the prevention and treatment of heart failure

心力衰竭是各种心血管疾病的严重阶段,严重危害人类的生命健康。黄芪甲苷Ⅳ是中药黄芪的主要有效成分,对心力衰竭有很好的防治作用,作用机制可能与其改善心功能和结构紊乱、减轻心脏损伤、抑制炎症反应、降低氧化应激反应、抑制细胞凋亡、调控细胞自噬、调节钙离子代谢、调控线粒体能量代谢,促进血管生成和降低miRNA-1表达有关。本研究综述黄芪甲苷Ⅳ治疗心力衰竭的最新进展,为黄芪甲苷Ⅳ临床应用提供依据。

Heart failure(HF) is a serious stage of various cardiovascular diseases, gravely endangering human life and health. Astragaloside Ⅳ(AS-Ⅳ), the main effective component of Astragalus membranaceus, has a good preventive and therapeutic effect on HF, whose mechanism may be related to improving cardiac function and structural disorder, reducing cardiac injury, inhibiting inflammatory response, reducing oxidative stress response, inhibiting apoptosis, regulating autophagy, regulating calcium metabolism, regulating mitochondrial energy metabolism, promoting angiogenesis and reducing miRNA-1 expression. This review summarized the latest progress of AS-Ⅳ in the treatment of HF, so as to provide a basis for the clinical application of AS-Ⅳ.