丁苯酞联合低分子肝素治疗急性进展性脑梗死的临床疗效

Clinical Efficacy of Butylphthalide Combined with Low Molecular Weight Heparin in the Treatment of Acute Progressive Cerebral Infarction

目的:探讨丁苯酞联合低分子肝素治疗急性进展性脑梗死的临床疗效。方法:选取该院2020年1月—2021年12月收诊的急性进展性脑梗死患者120例,根据治疗方式不同分为对照组和研究组,每组60例、对照组采用低分子肝素治疗,研究组在对照组基础上加用丁苯酞治疗,比较两组治疗效果、神经功能评分、生活质量评分、血液流变学指标、不良反应。结果:研究组总有效率为96.67%,高于对照组的83.33%,差异有统计学意义(P<0.05);研究组NIHSS评分低于对照组,ADL评分高于对照组,差异有统计学意义(P<0.05);研究组低切率、血浆比黏度、纤维蛋白原、红细胞压积优于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丁苯酞联合低分子肝素治疗急性进展性脑梗死的效果较为明显,可改善神经功能、生活质量和血液流变学,具有应用安全性。

Objective:To investigate the clinical effect of butylphthalide combined with low molecular weight heparin in the treatment of acute progressive cerebral infarction.Methods:A total of 120 patients with acute progressive cerebral infarction admitted to our hospital from January 2020 to December 2021 were selected and divided into control group and study group according to different treatment methods,with 60 cases in each group.The control group was treated with low molecular weight heparin,and the study group was treated with butylphthalide on the basis of the control group.The therapeutic effect,neurological function score,quality of life score,hemorheology index and adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 96.67%,which was higher than 83.33%of the control group,and the difference was statistically significant(P<0.05).The NIHSS score of the study group was lower than that of the control group,and the ADL score was higher than that of the control group,the difference was statistically significant(P<0.05).The low shear rate,plasma viscosity,fibrinogen and hematocrit of the study group were better than those of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The effect of butylphthalide combined with low molecular weight heparin in the treatment of acute progressive cerebral infarction is obvious,which can improve neurological function,quality of life and hemorheology,and has application safety.