甲磺酸倍他司汀片及银杏叶提取物片在耳石症手法复位后残余症状中的治疗效果

Therapeutic Effect of Betahistine Mesylate Tablets and Ginkgo Biloba Extract on Residual Symptom After Manipulative Reduction of Otolithiasis

目的:探讨甲磺酸倍他司汀片及银杏叶提取物片在耳石症手法复位后残余症状中的治疗效果。方法:选取2019年1月—2022年1月河南省直第三人民医院收治的108例行传统手法复位成功后仍伴有残余症状的耳石症患者,按随机数字表法分为对照组及观察组,每组54例。对照组予以甲磺酸倍他司汀片治疗,观察组在对照组基础上联合银杏叶提取物片治疗,比较两组临床疗效、残余症状改善效果、不良反应及复发率。结果:观察组总有效率为94.44%,高于对照组的79.63%,差异有统计学意义(P<0.05);两组治疗后DHI、前庭症状指数评分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);随访6个月后,两组不良反应及复发率比较,差异无统计学意义(P>0.05)。结论:耳石症手法复位后残余症状患者应用甲磺酸倍他司汀片及银杏叶提取物片治疗可获良好疗效,残余症状改善效果更佳,且不良反应及复发率均较低。

Objective:To investigate the therapeutic effect of betahistine mesylate tablets and ginkgo biloba extract on residual symptoms after manipulative reduction of otolithiasis.Methods:From January 2019 to January 2022,108 cases of otolithiasis patients with residual symptoms after successful reduction by traditional manipulation in the Third People’s Hospital of Henan Province were selected,and divided into control group and observation group according to random number table method,with 54 cases in each group.The control group was treated with betahistine mesylate,and the observation group was treated with ginkgo biloba extract on the basis of the control group.The clinical efficacy,residual symptom improvement effect,adverse reaction and recurrence rate were compared between the two groups.Results:The total effective rate of the observation group was 94.44%,which was higher than 79.63%of the control group,and the difference was statistically significant(P<0.05).The DHI and vestibular symptom index scores of the two groups after treatment were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After 6 months of follow-up,there was no significant difference in the adverse reactions and recurrence rates between the two groups(P>0.05).Conclusion:Betahistine mesylate tablets and ginkgo biloba extract in the treatment of residual symptoms of patients with otolithiasis after manual reduction can achieve good curative effect,the residual symptoms are better improved,and the adverse reactions and recurrence rates are lower.