射血分数降低心力衰竭患者血清G-17水平检测及其意义

Detection of Serum G-17 Level in Heart Failure Patients with Reduced Ejection Fraction and its Significance

目的 探讨射血分数降低心力衰竭(HFrEF)患者G-17表达水平及其意义。方法 选取2019年1月1日-2021年12月30日广西中医药大学附属瑞康医院心内科住院治疗的患者160例作为研究对象,将符合HFrEF诊断标准的80例患者作为心力衰竭组,另将同期住院匹配的80例非心力衰竭患者作为对照组,比较心力衰竭组和对照组及不同NYHA分级患者NTproBNP、LVEF、G-17水平,并分析血清G-17水平与NT-proBNP、LVEF的相关性。结果 心力衰竭组NT-proBNP、G-17水平高于对照组、而LVEF低于对照组,差异有统计学意义(P<0.05);心力衰竭组NYHAⅢ、Ⅳ级NT-proBNP水平高于NYHAⅡ级、而LVEF低于NYHAⅡ级;NYHAⅢ、Ⅳ级组血清G-17水平均高于NYHAⅡ级组,差异有统计学意义(P<0.05);Pearson相关性分析显示,G-17与NT-proBNP呈正相关(r=0.4708,P<0.05),与LVEF呈负相关(r=-0.5028,P<0.05)。结论 HFrEF患者血清G-17表达水平较高,血清G-17水平与NT-proBNP、LVEF密切相关,而G-17表达异常可能参与了心力衰竭发生发展的进程,有可能成为HFrEF患者重要的风险预测因子,具有潜在的临床应用价值。

Objective To investigate the expression level and significance of G-17 in patients with heart failure with reduced ejection fraction.Methods A total of 160 patients hospitalized in the Department of Cardiology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine from January 1,2019 to December 30,2021 were selected as the study subjects.Eighty patients who met the diagnostic criteria for HFrEF were included in the heart failure group,and 80 non-heart failure patients who were hospitalized during the same period were included in the control group.The levels of NT-proBNP,LVEF,and G-17 were compared between the heart failure group and the control group,as well as patients with different NYHA grades.The correlation between serum G-17 levels and NT-proBNP and LVEF was analyzed.Results The levels of NT-proBNP and G-17 in the heart failure group were higher than those in the control group,while the LVEF was lower than that in the control group,the difference was statistically significant(P<0.05).The NT-proBNP level of NYHAⅢ and Ⅳ in heart failure group was higher than that of NYHAⅡ,while LVEF was lower than that of NYHAⅡ,the serum G-17 level in NYHAⅢ and Ⅳ groups was higher than that in NYHAⅡ group,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that G-17 was positively correlated with NT-proBNP( r=0.4708,P<0.05) and negatively correlated with LVEF(r=-0.5028,P<0.05).Conclusion The expression level of serum G-17 in patients with HFrEF is higher,and the level of serum G-17 is closely related to NT-proBNP and LVEF.The abnormal expression of G-17 may be involved in the development of heart failure,which may be an important risk predictor for HFrEF patients and has potential clinical application value.