阿昔洛韦片联合重组人干扰素α-2b喷雾剂在儿童水痘治疗中的作用

Effect of Acyclovir Tablets Combined with Recombinant Human Interferon α-2b Spray in the Treatment of Varicella in Children

目的 研究阿昔洛韦片联合重组人干扰素α-2b喷雾剂在儿童水痘治疗中的作用。方法 选取2020年5月-2021年5月我院诊治的84例水痘儿童为研究对象,采用随机数字表法分为对照组和观察组,各42例。对照组采用阿昔洛韦片治疗,观察组在对照组基础上联合重组人干扰素α-2b喷雾剂治疗,比较两组临床疗效、临床康复指标、临床症状评分、炎性因子指标以及临床不良反应发生率。结果 观察组治疗总有效率为95.24%,高于对照组的83.33%(P<0.05);观察组退热时间、水痘停止发作时间、水痘结痂时间、住院时间均短于对照组(P<0.05);观察组临床瘙痒、皮疹、疼痛评分低于对照组(P<0.05);观察组hs-CRP、WBC水平低于对照组(P<0.05);观察组临床不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论 阿昔洛韦片联合重组人干扰素α-2b喷雾剂治疗儿童水痘效果良好,可改善患儿临床症状,缩短退热、水痘停止发作、结痂以及住院时间,减轻炎症反应,进一步促进患儿快速康复,且联合治疗不增加不良反应发生几率,安全性较高。

Objective To study the effect of acyclovir tablets combined with recombinant human interferon α-2b spray in the treatment of varicella in children.Methods A total of 84 children with varicella diagnosed and treated in our hospital from May 2020 to May 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 42 cases in each group.The control group was treated with acyclovir tablets,and the observation group was treated with recombinant human interferon α-2b spray on the basis of the control group.The clinical efficacy,clinical rehabilitation index,clinical symptom score,inflammatory factor index and incidence of clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.24%,which was higher than 83.33% in the control group(P0.05).Conclusion Aciclovir tablets combined with recombinant human interferon α-2b spray is effective in the treatment of varicella in children,which can improve the clinical symptoms of children,shorten the time of fever,varicella cessation,crusting and hospitalization,reduce the inflammatory reaction,and further promote the rapid recovery of children.And the combined treatment does not increase the incidence of adverse reactions,with high safety.