丁苯酞序贯治疗对急性进展性脑梗死患者神经功能、炎症因子及Hcy、NSE的影响

Effect of Butylphthalide Sequential Therapy on Neurological Function,Inflammatory Factors,Hcy and NSE in Patients with Acute Progressive Cerebral Infarction

目的 研究丁苯酞序贯治疗对急性进展性脑梗死患者神经功能、炎症因子及Hcy、NSE的影响。方法 选取2020年7月-2021年7月在我院诊治的90例急性进展性脑梗死患者为研究对象,采用随机数字表法分为对照组和观察组,各45例。对照组采用抗血小板常规治疗,观察组在对照组基础上采用丁苯酞序贯治疗,比较两组临床总有效率、神经功能缺损评分、炎症因子水平、同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)以及不良反应发生情况。结果 观察组治疗总有效率为95.56%,高于对照组的84.44%(P<0.05);两组神经功能缺损评分均低于治疗前,且观察组低于对照组(P<0.05);两组超敏-C反应蛋白(hsCRP)、白介素-6(IL-6)水平均低于治疗前,且观察组低于对照组(P<0.05);两组Hcy、NSE均低于治疗前,且观察组低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 丁苯酞序贯治疗急性进展性脑梗死效果确切,治疗总有效率高,可降低神经功能缺损评分、炎症因子水平、Hcy、NSE,且不会增加不良反应,是一种安全、有效的治疗方法。

Objective To study the effect of butylphthalide sequential therapy on neurological function,inflammatory factors,Hcy and NSE in patients with acute progressive cerebral infarction.Methods A total of 90 patients with acute progressive cerebral infarction diagnosed and treated in our hospital from July 2020 to July 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 45 cases in each group.The control group was treated with conventional antiplatelet therapy,and the observation group was treated with butylphthalide sequential therapy on the basis of the control group.The clinical total effective rate,neurological deficit score,inflammatory factor level,homocysteine(Hcy),neuron-specific enolase(NSE) and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.56%,which was higher than 84.44% in the control group( P 0.05).Conclusion Butylphthalide sequential therapy is effective in the treatment of acute progressive cerebral infarction,the total effective rate is high,and can reduce neurological deficit score,inflammatory factor level,Hcy and NSE,and will not increase adverse reactions.It is a safe and effective treatment method.