《欧洲内分泌学会临床实践指南:妊娠期功能性和无功能性垂体腺瘤》指南解读

Interpretation of ESE Clinical Practice Guideline on Functioning and Non-functioning Pituitary Adenomas in Pregnancy

垂体腺瘤(PA)通常引起性腺轴的损害,导致女性患者的生育能力下降。妊娠可使垂体增大,而性腺轴的激素分泌也随之发生相应改变。因此,对患有PA的妊娠妇女的规范化管理显得尤为重要。2021年8月,欧洲内分泌学会(ESE)发布了关于妊娠期功能性和无功能性PA的临床指南,该指南从腺瘤的大小、位置和有无内分泌功能方面,描述了从妊娠前到分娩后诊断、治疗的时机和选择。本文在ESE指南的基础上,对该指南进行了解读,总结了该指南的要点,以期结合中国的临床经验及患者特点,为临床医师管理此类患者提供具有实践意义的指导意见。

Pituitary adenomas usually cause damage to the gonadal axis,leading to a decrease in fertility in female patients.As pituitary gland enlarges during pregnancy,the hormone secretion of the gonadal axis changes accordingly.Therefore,it is particularly important to standardizedly manage pregnant women with pituitary adenomas.To this end,the European Society of Endocrinology(ESE) published Clinical Practice Guideline on Functioning and Non-functioning Pituitary Adenomas in Pregnancy in August 2021,which details the timing and methods selection of diagnosis and treatment of pituitary adenomas from preconception to postpartum in terms of size,location,and endocrine function of adenomas.We interpreted this guideline and summarized its main points,with a view to providing practical guidance for Chinese clinicians to manage such patients based on relevant clinical evidence and patient characteristics in China.