益气活血化痰通络汤对气虚血瘀型脑梗死恢复期应用价值分析

Analysis of the Application Value of Yiqi Huoxue Huatan Tongluo Decoction in the Recovery Period of Cerebral Infarction of Qi Deficiency and Blood Stasis Type

目的:探究益气活血化痰通络汤对气虚血瘀型脑梗死(CI)恢复期患者凝血功能的影响。方法:前瞻性选取河南省洛阳仁大医院132例气虚血瘀型CI恢复期患者,按随机数字表法分成中西医组、西医组。每组66例,西医组西医常规治疗,中西医组于西医组基础上接受益气活血化痰通络汤辅助治疗。对比2组总有效率、治疗前、治疗2个月中医证候积分、脑血流动力学指标[PI(搏动指数)、Vm(双侧脑动脉血流速度平均值)、Vs(收缩期值)]、血清NSE(神经元特异性烯醇化酶)、S100-β(中枢神经特异蛋白)、凝血功能[PT(凝血酶原时间)、APTT(活化部分凝血活酶时间)、FIB(纤维蛋白原)]水平。结果:中西医组总有效率92.42%(61/66)较西医组75.76%(50/66)高(P<0.05);治疗2个月中西医组感觉异常、口眼歪斜、语言謇涩、半身不遂中医证候积分较西医组低(P<0.05);治疗2个月中西医组Vs、Vm较西医组高,PI较西医组低(P<0.05);治疗2个月中西医组血清NSE、S100-β水平较西医组低(P<0.05);治疗2个月中西医组PT、APTT、FIB较西医组优(P<0.05)。结论:益气活血化痰通络汤辅助西医常规治疗气虚血瘀型CI恢复期患者疗效明显,可有效改善神经功能,优化脑血流动力学指标及凝血功能指标,促进病情恢复。

Objective:To explore the effect of Yiqi Huoxue Huatan Tongluo Decoction on coagulation function in patients with cerebral infarction(CI)convalescent with Qi deficiency and blood stasis type.Methods:A prospective study of 132 patients with CI convalescence of Qi deficiency and blood stasis type from Renda Hospital of Luoyang,Henan Province was selected,and they were divided into Chinese and Western medicine group and Western medicine group according to the random number table method.There were 66 cases in each group,the western medicine group received routine treatment of western medicine,and the traditional Chinese and western medicine group received the auxiliary treatment of Yiqi Huoxue Huatan Tongluo Decoction on the basis of the western medicine group.The total effective rate,TCM syndrome score,cerebral hemodynamic index[PI(pulsatility index),Vm(average value of bilateral cerebral artery blood flow velocity),Vs(systolic value)were compared between the two groups.],serum NSE(neuron-specific enolase),S100-β(central nervous system-specific protein),coagulation function[PT(prothrombin time),APTT(activated partial thromboplastin time),FIB(fibrin original)]level.Results:The total effective rate of TCM and Western medicine group was 92.42%(61/66)higher than that of Western medicine group 75.76%(50/66)(P<0.05).The TCM syndrome score of hemiplegia was lower than that of the western medicine group(P<0.05);the Vs and Vm of the traditional Chinese and western medicine group were higher than those of the western medicine group after 2 months of treatment,and the PI was lower than that of the western medicine group(P<0.05).,S100-βlevels were lower than those in the western medicine group(P<0.05);PT,APTT and FIB in the Chinese and western medicine group were better than those in the western medicine group after 2 months of treatment(P<0.05).Conclusion:Yiqi Huoxue Huatan Tongluo Decoction assisting conventional western medicine in the treatment of convalescent CI patients with Qi deficiency and blood stasis type has obvious curative effect,can effectively improve neurological function,optimize cerebral hemodynamic indexes and coagulation function indexes,and promote the recovery of the disease.