阿司匹林联合他汀类药物治疗脑血栓的临床疗效及对动脉斑块的影响

Clinical efficacy of aspirin combined with statins in the treatment of cerebral thrombosis and its effect on arterial plaque in patients

目的分析阿司匹林联合他汀类药物治疗脑血栓患者的临床疗效及对患者动脉斑块的影响。方法选取2018年3月至2020年3月本院收治的90例脑血栓患者作为研究对象,按照随机数字表法分为对照组和观察组,每组45例。对照组给予阿司匹林治疗,观察组给予阿托伐他汀联合阿司匹林治疗,比较两组临床疗效、动脉斑块面积及颈动脉内膜-中层厚度(IMT)及不良反应发生率。结果观察组治疗总有效率(95.56%)高于对照组(82.22%),差异有统计学意义(P<0.05)。治疗前,两组动脉斑块面积及颈动脉IMT比较差异无统计学意义;对照组治疗前后动脉斑块面积、颈动脉IMT比较差异无统计学意义;治疗后,观察组动脉斑块面积小于治疗前,颈动脉IMT薄于治疗前,且观察组动脉斑块面积小于对照组,颈动脉IMT薄于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无无统计学意义。结论阿司匹林联合他汀类药物治疗脑血栓效果显著,能改善患者动脉斑块面积及颈动脉IMT,且安全性较高,值得临床推广应用。

Objective To analyze the clinical efficacy of aspirin combined with statins in the treatment of cerebral thrombosis and its effect on arterial plaque in patients.Methods A total of 90 patients with cerebral thrombosis treated in our hospital from March 2018 to March 2020 were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,with 45 cases in each group.The control group was given aspirin treatment,and the observation group was given atorvastatin combined with aspirin treatment,the clinical efficacy,arterial plaque area and carotid intima-media thickness(IMT)and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(95.56%)was higher than that in the control group(82.22%),and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in arterial plaque area and carotid IMT between the two groups;there was no significant difference in arterial plaque area and carotid IMT in the control group before and after treatment;after treatment,the arterial plaque area in the observation group was smaller than before treatment,the carotid IMT was thinner than before treatment,and the arterial plaque area in the observation group was smaller than that in the control group,and the carotid IMT was thinner than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Aspirin combined with statins has significant effect in the treatment of cerebral thrombosis,can significantly improve the patient's arterial plaque area and carotid artery IMT,and has highd safety,which is worthy of clinical application.