免疫检查点抑制剂治疗肝细胞癌的机制探讨

Mechanism of immune checkpoint inhibitors in the treatment of hepatocellular carcinoma

免疫检查点抑制剂(ICI)的应用开启了肿瘤治疗的新纪元,是现在肿瘤治疗的热门疗法。但ICI在各种癌症的治疗效果上存在着不小的差异,我们需要对其效应机制及存在的缺陷进行进一步探索,来找到对患者的最优治疗方案。ICI引起的免疫效应的增强对肿瘤微环境具体产生何种影响,这些都应该在肿瘤治疗当中被考虑进去。本文将对ICI在肝细胞癌的治疗中可能产生的效应结合临床研究进行综述。

The application of immune checkpoint inhibitors(ICI) has opened a new era of tumor treatment and is a popular therapy for tumor treatment.However, there are some big differences in the effect of ICI on the treatment of various cancers.We need to further explore its effect mechanism and defects to find the optimal treatment plan for patients.The specific effects of the enhanced immune effect caused by ICI on the tumor microenvironment should be taken into account in the treatment of cancer.This article will review the possible effects of ICI in the treatment of hepatocellular carcinoma combined with clinical research.