肝硬化相关性肌减少发生与肠道菌群失调、幽门螺杆菌感染的相关性分析

Correlation of hepatic cirrhosis⁃related sarcopenia with gut microbiota dysbiosis and Helicobacter pylori infection

目的:研究肝硬化患者肌减少的发生与肠道菌群失调、幽门螺杆菌感染的相关性。方法:选择2021年1月⁃2022年1月在广州医科大学附属第二医院消化内科住院的肝硬化患者进行肌减少评估、甲烷⁃氢呼气试验、C13⁃幽门螺杆菌呼气试验,分析肌减少的发生与肠道细菌过度生长、幽门螺杆菌感染之间的相关性。结果:肝硬化患者肌减少的发生率高达50.85%,并随肝功能分级的进展,肌减少发生率上升(P<0.05);肝硬化患者肌减少的发生与肠道细菌过度生长呈正相关(χ^(2)=3.33,P<0.01);肝硬化患者肌减少的发生与幽门螺杆感染呈正相关(χ^(2)=4.05,P<0.05)。结论:通过检测肝硬化患者肠道菌群是否失衡,可初步提示患者肌减少发生的风险程度。肝硬化合并幽门螺杆菌感染的患者需及时根治,同时加强健康教育以预防肌减少的发生。

Objective:To investigate the correlation of hepatic cirrhosis⁃related sarcopenia with gut microbiota dysbiosis and Helicobacter pylori infection.Methods:The patients hospitalized in the Department of Gastroenterology,Second Affiliated Hospital of Guangzhou Medical University between January 2021 and January 2022 underwent assessment for sarcopenia,methane⁃hydrogen breath test and C13⁃urea breath test for Helicobacter pylori.Pearson’s chi⁃square test was used to determine the correlation of hepatic cirrhosis⁃related sarcopenia with gut microbiota overgrowth and Helicobacter pylori infection.Results:The prevalene of sarcopenia in patients with hepatic cirrhosis was up to 50.85%,and the incidence of sarcopenia increased along with higher Child⁃Pugh classification of liver function(P<0.05).The sarcopenia in patients with hepatic cirrhosis was positively correlated with the overgrowth of gut microbiota(χ^(2)=3.33,P<0.01),and was positively correlated also with Helicobacter pylori infection(χ^(2)=4.05,P<0.05).Conclusion:Detection of gut microbiota dysbiosis may preliminarily indicate the risk of sarcopenia.Hepatic cirrhosis complicated with Helicobacter pylori infection needs timely eradication therapy.In addition,health education should be strengthened to prevent sarcopenia.