牛病毒性腹泻病毒结构蛋白功能研究进展

Research Progress on the Function of the Structural Proteins of the Bovine Viral Diarrhea Virus

牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)基因组为单股正链RNA,编码4种结构蛋白(C、E、E1和E2)和8种非结构蛋白(N、p7、NS2、NS3、NS4A、NS4B、NS5A和NS5B)。牛感染BVDV后可出现腹泻、流产、繁殖障碍、持续感染等症状,该病死亡率较高,对我国乃至世界养牛业均造成了严重影响。因此,本文就BVDV已确定的4种结构蛋白的功能进行了概括性总结,以期为BVDV的深入研究提供理论依据和参考。

The genome of the bovine viral diarrhea virus(BVDV)is a single-stranded,positive-stranded RNA.It encodes four structural proteins(C,Erns,E1 and E2)and eight non-structural proteins(Npro,p7,NS2,NS3,NS4A,NS4B,NS5A and NS5B).Diarrhea,abortion,reproductive disturbance and persistent infection may occur in cattle infected with the BVDV.The mortality rate of bovine viral diarrhea is high,and has a serious impact on the cattle industry in China and worldwide.Here,we summarize the functions of the four structural proteins identified in the BVDV.In this way,we provide a theoretical basis and reference for further study of the BVDV.