复方皂矾丸联合重组人粒细胞刺激因子治疗肿瘤化疗后白细胞减少症的疗效观察

Efficacy of Compound Zaofan Pills Combined with Recombinant Human Granulocyte Colony-Stimulating Factor in the Treatment of Leukopenia After Tumor Chemotherapy

目的:探讨复方皂矾丸联合重组人粒细胞刺激因子(rhG-CSF)治疗肿瘤化疗后白细胞减少症的疗效。方法:选取2021年该院收治的94例化疗后白细胞减少症患者,根据随机数字表法分为对照组和观察组,每组47例。对照组患者接受rhG-CSF治疗,观察组患者接受复方皂矾丸联合rhG-CSF治疗。比较两组患者的临床疗效,中医证候积分,不良反应发生情况,外周血白细胞计数(WBC)、中性粒细胞计数(NEUT),CD3^(+)、CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+)水平。结果:观察组患者的总有效率为89.36%(42/47),明显高于对照组的72.34%(34/47),差异有统计学意义(P<0.05)。治疗后,两组患者中医证候积分和外周血CD8^(+)水平明显降低,外周血WBC、NEUT、CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)水平明显升高;且观察组患者中医证候积分和外周血CD8^(+)水平明显低于对照组,外周血WBC、NEUT、CD3^(+)、CD4^(+)和CD4^(+)/CD8^(+)水平明显高于对照组,差异均有统计学意义(P<0.05)。对照组、观察组患者的不良反应发生率分别为17.02%(8/47)、12.77%(6/47),两组比较的差异无统计学意义(P>0.05)。结论:复方皂矾丸联合rhG-CSF治疗肿瘤化疗后白细胞减少症的疗效显著,能有效提升白细胞数量,改善免疫功能,且安全性高。

OBJECTIVE:To probe into the efficacy of compound Zaofan pills combined with recombinant human granulocyte colony-stimulating factor(rhG-CSF)in the treatment of leukopenia after tumor chemotherapy.METHODS:A total of 94 patients with leukopenia after tumor chemotherapy admitted into the hospital in 2021 were extracted to be divided into the control group and the observation group via the random number table method,with 47 cases in each group.The control group received rhG-CSF treatment,while the observation group was given compound Zaofan pills combined with rhG-CSF treatment.The clinical efficacy,traditional Chinese medicine syndrome score,incidence of adverse drug reactions,peripheral blood white blood cell(WBC)count,neutrophil count(NEUT),CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)were compared between two groups.RESULTS:The total effective rate of the observation group was 89.36%(42/47),significantly higher than 72.34%(34/47)of the control group,the difference was statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome score and peripheral blood CD8^(+)levels decreased significantly,while peripheral blood WBC,NEUT,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)levels increased significantly in two groups;the traditional Chinese medicine syndrome score and peripheral blood CD8^(+)levels of the observation group were significantly lower than those of the control group,and the peripheral blood WBC,NEUT,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)levels of the observation group were significantly higher than those of the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the control group and the observation group were respectively 17.02%(8/47)and 12.77%(6/47),and there was no significant difference between two groups(P>0.05).CONCLUSIONS:The efficacy of Zaofan pills combined with rhG-CSF in the treatment of leukopenia after tumor chemotherapy is significant,which can effectively increase the WBC and improve the immune function with higher safety.