大气颗粒物与精神分裂症发病关联的流行病学研究进展

Association between atmospheric particulate matter and schizophrenia:a review of epidemiological studies

精神分裂症是一种常见的严重精神障碍,发病受到基因和环境因素的共同影响。现有研究发现大气颗粒物与精神分裂症间存在相关性,其中细颗粒物(PM_(2.5))和可吸入颗粒物(PM_(10))短期暴露对精神分裂症可能存在滞后效应和累积效应。本文收集国内外相关研究文献,对PM_(2.5)、PM_(10)暴露与精神分裂症发病相关性进行综述,为精神分裂症防制提供依据。

Schizophrenia is a common serious mental disorder,and genetic and environmental factors jointly contribute to the pathogenesis of schizophrenia.A correlation has been found between atmospheric particulate matter and the risk of schizophrenia,and short-term exposure to fine particulate matter(PM_(2.5))and inhalable particulate matter(PM_(10))may pose lagged and cumulative effects on the development of schizophrenia.Based on review of national and international publications,this review summarizes the associations between exposure to PM_(2.5) and PM_(10) and the risk of schizophrenia,so as to provide insights into the management of schizophrenia.