肾病综合征患儿发生激素性高眼压干预时机的研究

Study on the intervention opportunity for children with nephrotic syndrome and hormonal ocular hypertension

目的探讨发生激素性高眼压的肾病综合征儿童高眼压的干预时机。方法选取2016年7月至2018年1月治疗的108例原发性肾病综合征患儿,记录激素治疗前后患者眼压、眼轴和屈光度变化情况,将应用糖皮质激素治疗6个月内眼压升高的22例患者纳入观察组,将眼压未明显升高的86例患者纳入对照组。分析2组患者的眼压与眼轴、屈光度的关系。结果观察组患者眼压使用激素后明显增高,对照组眼压升高不明显,2组眼压差异有统计学意义(P<0.05);受高眼压的影响,观察组眼轴较对照组眼轴更长(P<0.05),观察组生理性远视的屈光度较对照组明显减少(P<0.05),甚至出现负值,更快的发展为近视眼。结论高眼压对患者的视力造成不利影响,需要及时对高眼压进行干预,以防止患者视力的下降。

Objective To investigate the the intervention opportunity for children with nephrotic syndrome and hormonal ocular hypertension.Methods A total of 108 patients with primary nephrotic syndrome who were treated by glucocorticoids in our hospital from July 2016 to January 2018 were enrolled in the syudy,and the changes of hormone eye axis and diopter intraocular pressure before and after treatment were observed,of whom,the 22 patients with elevated intraocular pressure after 6-month treatment were enrolled as observation group,and the other 86 patients without elevated intraocular pressure were enrolled in the control roup.The correlation between intraocular pressure and axis oculi as well as diopter was analyzed.Results After treatment,the intraocular pressure in observation group was significantly higher than that in control group(P<0.05),and the axis oculi in observation group was significantly longer than that in control group(P<0.05).However the diopter in observation group was significantly lower than that in control group(P<0.05),and even showed negative values,which developed into myopia more quickly.Conclusion The high intraocular pressure has adverse effects on the visual acuity of patients,therefore,it is necessary to interfere in the high intraocular pressure,so as to prevent the decline of vision.