天津市三级综合医院疫情期间医护人员代谢综合征与高同型半胱氨酸血症的关系及靶器官损害的研究

Study on the relationship of metabolic syndrome and hyperhomocysteinemia and target organ damage among medical staff in a Tianjin third-class general hospital during the pandemic period

目的了解疫情期间医护人员代谢综合征(MS)、高同型半胱氨酸血症(HHcy)的患病率、二者关系及靶器官损害。方法选取2020年1月—2021年11月在天津市某三级综合医院的1544名医护人员作为研究对象。测量人体指标,测定血液生化、免疫等指标。分析MS及其组分的患病率、HHcy的患病率及靶器官损害。采用χ^(2)检验,比较MS组、HHcy组与对照组靶器官损害的差异。采用Logistic回归模型分析MS与HHcy的关系。结果三级综合医院医护人员疫情期间MS患病率为23.7%,MS组分:中心性肥胖、高血压/高血压病、高甘油三酯、低高密度脂蛋白和高空腹葡萄糖/糖尿病的患病率分别为49.4%、19.3%、24.3%、0.5%和37%。HHcy的患病率为29.7%。MS组、HHcy组与对照组靶器官损害程度差异有统计学意义(P<0.001)。HHcy与MS无直接相关性。结论疫情期间医护人员MS和HHcy患病率较高,与对照组相比有明显的靶器官损害,HHcy不是MS的独立危险因素。

Objective To explore the prevalence of metabolic syndrome(MS)and hyperhomocysteinemia(HHcy),their relationship and target organ damage among medical staff during the pandemic.Methods A total of 1544 medical staff in a third-class general hospital in Tianjin from January 2020 to November 2021 were selected as the object of study.The indexes of human body were measured,and the indexes of blood biochemistry and immunity were detected.The prevalence of MS and its components,the prevalence of HHcy and target organ damage were analyzed.χ^(2) test was used to analyze the difference of target organ damage among MS group,HHcy group and control group.The relationship between HHcy and MS was analyzed by Logistic regression model.Results The prevalence of MS among medical staff in the third-class general hospital during the pandemic was 23.7%.The prevalence of central obesity,hypertension/hypertension disease,high triglyceride,low high density lipoprotein cholesterol and high fasting plasma glucose/diabetes were 49.4%,19.3%,24.3%,0.5%and 37%,respectively.The prevalence of HHcy was 29.7%.There was significant difference in target organ damage among MS group,HHcy group and control group(P<0.001).There was no direct correlation between HHcy and MS.Conclusions During the pandemic period,the prevalence of MS and HHcy in medical staff were high,and there was obvious target organ damage in those staff compared with the control staff.HHcy is not an independent risk factor of MS.