厄贝沙坦联合肾炎康复片治疗慢性肾炎的药学分析及对肾功能的影响

Pharmacological analysis of irbesartan and Shenyan Kangfu Tablet in the treatment of chronic ne-phritis and its effect on renal function

目的探讨在慢性肾炎中采用厄贝沙坦+肾炎康复片对肾功能的影响。方法在我院肾内科2018年3月—2020年8月收治的慢性肾炎患者中随机选取80例,按照抽签法分为2组,对照组(40例)采用厄贝沙坦,研究组在其基础上加用肾炎康复片,对比2组肾功能指标、临床疗效及不良反应。结果治疗后2组肾功能指标均好转,且研究组血肌酐、尿素氮、24 h尿蛋白量均低于对照组,肾小球滤过率高于对照组(P<0.05)。2组治疗总有效率对比差异显著(P<0.05),不良反应对比无差异。结论在对慢性肾炎的治疗中联用厄贝沙坦及肾炎康复片可有效提高肾功能,疗效显著。

Objective To investigate the effect of irbesartan and Shenyan Kangfu Tablet on renal function in chronic nephritis.Methods A total of 80 patients of chronic nephritis admitted in our hospital from March 2018 to August 2020 were randomly selected and divided into two groups by drawing lots.The control group(40 cases)received irberartan,while the research group added Shenyan Kangfu Tablet on the basis of irberartan.The renal function indexes,clinical efficacy and adverse reactions of the two groups were compared.Results After treatment,renal function indexes in both groups were improved,and serum creatinine,urea nitrogen and 24 h urinary protein levels in the research group were lower than those in the control group,and glomerular filtration rate was higher than that in the control group(P<0.05).The total effective rate was significantly different between the two groups(P<0.05),but there was no difference in adverse reaction rate.Conclusions In the treatment of chronic nephritis,irbesartan combined with Shenyan Kangfu Tablets could effectively improve renal function,and the effect is significant.