美多巴联合盐酸司来吉兰治疗帕金森患者的临床效果及影响

Clinical effect and influence of medopa combined with selegilan hydrochloride in the treatment of patients with Parkinson's disease

目的探讨美多巴联合盐酸司来吉兰治疗帕金森患者的临床效果及对不良反应情况的影响。方法选取我院2018年1月—2020年12月收治的96例帕金森患者,通过单双号抽签法将96例患者分为2组,分别为对照组、观察组(每组48例)。对照组给予美多巴治疗,观察组在美多巴联合盐酸司来吉兰进行治疗。然后对比2组患者治疗前后的临床疗效,采用帕金森统一评分量表计算精神状态、运动功能和日常活动评分并记录不良反应的发生率。结果对比2组患者治疗前后临床疗效,观察组患者临床总有效率高于对照组(87.50%vs 66.66%),差异有统计学意义(χ^(2)=5.897,P=0.015);治疗后2组患者精神状态、运动功能和日常活动评分低于治疗前(P<0.05),且观察组患者各项评分低于对照组,差异有统计学意义(t=8.250,P<0.001;t=4.388,P=<0.001;t=3.207,P=0.002);对比2组患者不良反应发生率,对照组与观察组不良反应发生率比较无差异(10.41%vs 12.50%,χ^(2)=0.103,P=0.749),2组患者治疗后的不良反应均为一过性,停药或休息后可自行缓解。结论美多巴联合盐酸司来吉兰治疗帕金森患者的临床疗效良好,能让患者精神状态、运动功能和日常生活得到显著改善,且不良反应较少。

Objective To explore the clinical effect of medopa combined with selegiline hydrochloride in the treat-ment of patients with Parkinson's disease and its impact on adverse reactions.Methods A total of 96 Parkinson's disease pa-tients from January 2018 to December 2020 were selected and divided into two groups by the odd and even number drawing method,48 cases each.The control group was treated with medopa,and the observation group was treated with selegiline hydrochloride on the basis of the control group.Then the clinical efficacy of the two groups were compared,and the Unified Parkinson's Disease Rating Scale was used to access the mental state,motor function and daily activity scores of the patients,and the incidence of adverse reactions was recorded.Results The total effective rate of the observation group was higher than that of the control group(87.50%vs 66.66%),with statistical significance(χ^(2)=5.897,P=0.015).After treat-ment,the scores of mental state,motor function and daily activities were lower(P<0.05),and the scores of the observation group were significantly lower than those of the control group(t=8.250,P<0.001;t=4.388,P=<0.001;t=3.207,P=0.002);the incidence of adverse reactions had no differences(10.41%vs 12.50%,χ^(2)=0.103,P=0.749).The ad-verse reactions were transient,which could be alleviated by drug withdrawal or rest.Conclusions Madopa combined with selegiline hydrochloride had a good clinical effect in the treatment of patients with Parkinson's disease.It could significantly improve the mental state,motor function and daily life of patients,with less adverse reaction,which is worthy of promotion.