PI3K/AKT信号通路在非创伤股骨头坏死的作用

Role of PI3K/Akt signaling pathway in non-traumatic necrosis of femoral head

非创伤性股骨头坏死(nontraumatic osteonecrosis of the femoral head, NONFH)是临床常见的骨科疾病,而血液循环障碍则是导致NONFH的主要病因之一,所以改善血液循环对NONFH的早中期阶段的预防和治疗具有重要的意义。多个信号通路都可以通过改善血液循环对NONFH起到防治作用,包括PI3K/AKT作为其中重要的信号通路可以通过调控上下游因子来改善血液循环,从而达到预防和治疗NONFH的作用。本文主要讨论PI3K/AKT信号通路通过影响导致血液循环障碍的众多因素(例如脂代谢紊乱和血管再生等方面)防治NONFH进行综述。通过影响血管内皮生长因子、P2Y12受体和一氧化氮合成酶等上下游因子调整和改善血液循环,从而为NONFH防治提供新的参考及依据。

Nontraumatic osteonecrosis of the femoral head(NONFH) is a common clinical orthopaedic disease, while blood circulation impairment has been considered as one of the main reasons of this disorder. Therefore, improving blood circulation is of great significance for the prevention and treatment of NONFH in the early and middle stages. Multiple signal pathways might prevent and treat NONFH by improving blood circulation, including PI3K/Akt signal pathway. This paper mainly discusses the role of PI3K/Akt signaling pathway in affecting NONFH by many factors related to blood circulation, such as lipid metabolism disorder and vascular regeneration. In addition, PI3K/Akt signaling pathway might improve blood circulation by affecting upstream and downstream factors such as vascular endothelial growth factor, P2Y12 receptor and nitric oxide synthase, so as to provide a new reference and basis for the prevention and treatment of NONFH.