摘要
嗜肺军团菌(Legionella pneumophila,L.pneumophila)是研究病原菌-宿主相互作用的重要模式菌株之一,其独特的分泌系统及底物效应蛋白的结构与功能是病原微生物领域的研究热点。Ⅱ型分泌系统(typeⅡsecretion system,T2SS)对促进细菌在环境和人类宿主中的生存至关重要。嗜肺军团菌Legionella secretion pathway(Lsp)系统是革兰氏阴性病原菌中一个典型的T2SS。本文综述了L.pneumophila的T2SS及其底物效应蛋白的研究进展,重点介绍其结构与功能,为深入了解革兰氏阴性病原菌的T2SS功能和作用机制提供参考。
Legionella pneumophila(L.pneumophila)is a distinct model for pathogen-host interaction research.Its unique secretion systems as well as the structures and functions of their substrate effectors are the research hotspots in the field of pathogenic microorganism.TypeⅡsecretion system(T2SS)plays a major role in promoting bacterial survival in the environment and in human hosts,and Legionella secretion pathway(Lsp)is a typical T2SS in Gram-negative pathogens.This review briefly summarizes the research progress of L.pneumophila T2SS and its substrate effectors,emphasizing on their structures and functions,so as to provide in-depth understanding of the function and mechanism of T2SS in Gram-negative pathogens.
作者
陈小芳
唐琪
张楠楠
葛宏华
CHEN Xiaofang;TANG Qi;ZHANG Nannan;GE Honghua(Institutes of Physical Science and Information Technology,Anhui University,Hefei 230601,Anhui,China;School of Resources and Environmental Engineering,Anhui University,Hefei 230601,Anhui,China;School of Life Sciences,Anhui University,Hefei 230601,Anhui,China)
出处
《微生物学通报》
CAS
CSCD
北大核心
2022年第9期3906-3918,共13页
Microbiology China
基金
国家自然科学基金(31970103)
安徽省重点研发计划(202004a06020035)
安徽省教育厅高校自然科学研究项目(K120462017)
中国博士后科学基金(2021M700178)。
关键词
嗜肺军团菌
Ⅱ型分泌系统
效应蛋白
结构与功能
Legionella pneumophila
type Ⅱ secretion system
effector
structures and functions