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胃癌患者血清Versican、CD163水平与临床病理特征的关系及其诊断价值

Relationship between serum Versican,CD163 levels and clinicopathological features in patients with gastric cancer and their diagnostic value
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摘要 目的探讨胃癌患者血清中Versican、CD163水平与临床病理特征的关系及其诊断价值。方法收集2019年1月至2021年8月郑州人民医院收治的80例胃癌患者为胃癌组,同时收集同时期于本院体检的80例健康体检者为健康体检组。用酶联免疫吸附试验(ELISA)检测血清中Versican和CD163水平;用免疫组织化学法检测胃癌组织和相应癌旁正常胃黏膜组织中Versican和CD163蛋白表达情况。分析胃癌患者血清Versican和CD163水平与临床病理特征的关系及其与组织中蛋白表达量的相关性;绘制血清Versican和CD163的受试者工作特征曲线,评估其对胃癌的诊断价值。结果胃癌组血清Versican和CD163水平显著高于健康体检组(P<0.05);胃癌组织中Versican和CD163蛋白表达量均高于癌正常胃黏膜组织(P<0.05)。患者的血清Versican和CD163水平与胃癌的分化程度、临床分期、浸润深度、淋巴结转移和远处转移显著相关(P<0.05)。血清Versican和CD163诊断胃癌的曲线下面积(AUC)分别为0.942和0.905。Spearman等级相关性分析结果显示,血清Versican和CD163水平与组织中蛋白表达量均呈正相关(r=0.722,P<0.001;r=0.676,P<0.001),血清Versican水平与CD163水平呈正相关(r=0.693,P<0.001)。结论胃癌患者血清Versican和CD163水平与胃癌的分化程度、临床分期、浸润深度、淋巴结转移和远处转移等临床病理特征有关,有望成为诊断胃癌的血清学标志物。 Objective To investigate the relationship between serum Versican,CD163 levels and clinicopathological features in patients with gastric cancer and their diagnostic value.Methods A total of 80 patients with gastric cancer admitted in People’s Hospital of Zhengzhou from January 2019 to August 2021 were collected as gastric cancer group,and the 80 healthy people who underwent physical examination in the hospital at the same time were collected as health examination group.The levels of serum Versican and CD163 were detected by enzyme-linked immunosorbent assay(ELISA);the expression of Versican and CD163 proteins in gastric cancer tissues and normal gastric mucosa tissues adjacent to cancer were detected by immunohistochemistry.The relationship between serum Versican,CD163 levels and clinicopathological features,and the correlation between serum Versican,CD163 levels and protein expression in tissues of patients with gastric cancer were analyzed;the receiver operating characteristic curve of serum Versican and CD163 were drawn to evaluate their diagnostic value for gastric cancer.Results The levels of serum Versican and CD163 of the gastric cancer group were significantly higher than those of the health examination group(P<0.05);the expression of Versican and CD163 proteins in gastric cancer tissue were significantly higher than those in normal gastric mucosa tissue adjacent to cancer(P<0.05).The levels of serum Versican and CD163 of patients were significantly correlated with the degree of differentiation,clinical stage,depth of invasion,lymph node metastasis and distant metastasis of gastric cancer(P<0.05).The area under the curve(AUC)of serum Versican and CD163 in the diagnosis of gastric cancer were 0.942 and 0.905,respectively.Spearman rank correlation analysis results showed that the levels of serum Versican and CD163 were positively correlated with the protein expression in tissues(r=0.722,P<0.001;r=0.676,P<0.001),and the level of serum Versican was positively correlated with the level of CD163(r=0.693,P<0.001).Conclusion The levels of serum Versican and CD163 in gastric cancer patients are related with the clinicopathological features such as degree of differentiation,clinical stage,depth of invasion,lymph node metastasis and distant metastasis.They are expected to become serological markers for gastric cancer.
作者 杨迷玲 杨金花 徐宪伟 方会娟 门颖丽 郝义彬 YANG Miling;YANG Jinhua;XU Xianwei;FANG Huijuan;MEN Yingli;HAO Yibin(People's Hospital of Henan University of Chinese Medicine/People's Hospital of Zhengzhou,Zhengzhou 450000,China)
出处 《临床医学研究与实践》 2022年第28期1-4,19,共5页 Clinical Research and Practice
基金 2018年河南省医学科技攻关计划省部共建项目(No.2018010043)。
关键词 胃癌 VERSICAN CD163 临床病理特征 gastric cancer Versican CD163 clinicopathological feature
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