醒脑静注射液联合阿替普酶治疗急性缺血性脑卒中的效果及对患者颅内血流速度、炎性因子水平的影响

Effect of Xingnaojing injection combined with alteplase in the treatment of acute ischemic stroke and its influences on intracranial blood flow velocity and inflammatory factors levels of patients

目的探讨醒脑静注射液联合阿替普酶治疗急性缺血性脑卒中的效果。方法选取2018年1月至2020年12月本院收治的96例急性缺血性脑卒中患者作为研究对象,遵循数字随机法将其分为参照组和联合组,各48例。参照组开展阿替普酶治疗,联合组开展醒脑静注射液联合阿替普酶治疗。比较两组的治疗效果。结果联合组的治疗总有效率为91.67%,高于参照组的72.92%,差异具有统计学意义(P<0.05)。治疗后,联合组的大脑后动脉(PCA)、椎动脉(VA)、基底动脉(BA)血流速度大于参照组,差异具有统计学意义(P<0.05)。治疗后,联合组的大脑前动脉、中动脉收缩期峰值血流速度、平均血流速度大于参照组,差异具有统计学意义(P<0.05)。治疗后,联合组的白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平低于参照组,差异具有统计学意义(P<0.05)。治疗后,联合组的同型半胱氨酸(HCY)、S100β蛋白、脂蛋白相关磷脂酶A2(Lp-PLA2)、神经元特异性烯醇化酶(NSE)水平低于参照组,差异具有统计学意义(P<0.05)。结论醒脑静注射液联合阿替普酶治疗急性缺血性脑卒中的效果较好,可提高颅内血流速度,降低炎性因子水平。

Objective To explore the effect of Xingnaojing injection combined with alteplase in the treatment of acute ischemic stroke.Methods A total of 96 patients with acute ischemic stroke admitted in our hospital from January 2018 to December 2020 were selected as the research objects.The patients were divided into reference group and combined group according to the digital randomization method,with 48 cases in each group.The reference group was treated with alteplase,and the combined group was treated with Xingnaojing injection combined with alteplase.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the combined group was 91.67%,which was higher than 72.92%in the reference group,and the difference was statistically significant(P<0.05).After treatment,the blood flow velocity of posterior cerebral artery(PCA),vertebral artery(VA)and basilar artery(BA)in the combined group were greater than those in the reference group,and the differences were statistically significant(P<0.05).After treatment,the peak systolic velocity and mean blood velocity of anterior cerebral artery and middle cerebral artery in the combined group were greater than those in the reference group,and the differences were statistically significant(P<0.05).After treatment,interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)levels in the combined group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,homocysteine(HCy),S100βprotein,lipoprotein-associated phospholipase A2(Lp-PLA2)and neuron-specific enolase(NSE)levels in the combined group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Xingnaojing injection combined with alteplase in the treatment of acute ischemic stroke has a good effect,which can improve the intracranial blood flow velocity and reduce the levels of inflammatory factors.