胆囊息肉样病变相关危险因素分析

Analysis of risk factors related to polypoid lesions of gallbladder

目的:探讨胆囊息肉样病变相关危险因素,为胆囊息肉样病变的综合防治提供依据。方法:回顾性分析2020年1月至2021年8月6603例在复旦大学附属中山医院青浦分院健康体检中心进行健康体检的普通人群作为研究对象,经超声诊断后分为胆囊息肉样病变组和非胆囊息肉样病变组,分析2组在性别、年龄、体重指数(BMI)、高血压、高血糖、高脂血症和高尿酸血症方面的差异,同时比较收缩压(SBP)、舒张压(DBP)、血清尿酸(SUA)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDH-C)水平,采用Logistic回归分析胆囊息肉样病变相关危险因素。结果:单因素分析发现2组在性别、年龄、BMI、高血压、高血糖、高脂血症和高尿酸血症方面差异均有统计学意义(P<0.05),且2组在SBP、DBP、SUA、FPG、TC、TG、LDL-C水平方面差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,性别(OR=3.272,95%CI:2.844~3.764)、年龄(OR=1.704,95%CI:1.485~1.956)、BMI(OR=1.209,95%CI:1.176~1.242)、高血压(OR=1.368,95%CI:1.131~1.654)、高血糖(OR=1.548,95%CI:1.075~2.230)为胆囊息肉样病变的独立危险因素(P<0.05)。结论:性别、年龄、BMI、高血压、高血糖为胆囊息肉样病变的独立危险因素,可以通过对BMI、高血压和高血糖进行早期干预来降低胆囊息肉样病变的发生率。

Objective:To analyze the risk factors related to polypoid lesions of gallbladder,in order to provide a basis for its comprehensive prevention and treatment.Methods:The clinical data of 6603 cases of general population who underwent physical examination in the physical examination center of Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University from Jan 2020 to Aug 2021 were retrospectively analyzed.They were divided into gallbladder polypoid lesions group and non-gallbladder polypoid lesions group.The differences in sex,age,body mass index(BMI),hypertension,hyperglycemia,hyperlipidemia and hyperuricemia between the two groups were analyzed.Systolic blood pressure(SBP),diastolic blood pressure(DBP),the levels of serum uric acid(SUA),fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)were also compared.Logistic regression was used to analyze the risk factors of polypoid lesions of gallbladder.Results:Univariable analysis showed that there were significant differences in sex,age,BMI,hypertension,hyperglycemia,hyperlipidemia and hyperuricemia between the two groups,and there were also differences in SBP,DBP,the levels of SUA,FPG,TC,TG and LDL-C.Logistic regression analysis showed that sex(OR=3.272,95%CI:2.844-3.764),age(OR=1.704,95%CI:1.485-1.956),BMI(OR=1.209,95%CI:1.176-1.242),hypertension(OR=1.368,95%CI:1.131-1.654)and hyperglycemia(OR=1.548,95%CI:1.075-2.230)were independent risk factors for polypoid lesions of gallbladder.Conclusions:Sex,age,BMI,hypertension and hyperglycemia are independent risk factorsfor polypoid lesions of gallbladder.Early intervention of BMI,hypertension and hyperglycemia can reduce the incidence of polypoid lesions of gallbladder.