白细胞计数、超敏C反应蛋白和T细胞亚群水平检测在儿童急性上呼吸道感染合并发热惊厥的诊断价值

Diagnostic Value of White Blood Cell Count,High-sensitivity C-reactive Protein and T Cell Subsets in Children with Acute Upper Respiratory Tract Infection Complicated by Febrile Seizures

目的研究分析白细胞计数、超敏C反应蛋白和T细胞亚群水平对儿童急性上呼吸道感染合并发热惊厥诊断的临床价值。方法选取2020年1月—2021年4月江苏大学附属宜兴医院收治的70例急性上呼吸道感染合并发热惊厥患儿为研究对象,根据病原体类型分为细菌组与病毒组,各35例,同时选取35名进行体检的健康儿童为对照组。对3组儿童白细胞计数、超敏C反应蛋白、T细胞亚群水平进行检测与比较。结果细菌组白细胞计数(19.15±3.68)×10^(9)/L,病毒组(4.58±1.22)×10^(9)/L,细菌组>对照组>病毒组,差异有统计学意义(F=383.968,P<0.05);细菌组超敏C反应蛋白(17.52±3.16)mg/L,病毒组(3.13±0.58)mg/L,细菌组>病毒组>对照组,差异有统计学意义(F=756.274,P<0.05)。细菌组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)分别为(41.46±7.73)%、(29.82±5.62)%、(0.97±0.35)与病毒组(42.18±7.25)%、(30.31±5.81)%、(1.02±0.36)均显著低于对照组,差异有统计学意义(F=38.738、20.514、18.221,P<0.05),细菌组与病毒组比较,差异无统计学意义(P>0.05);细菌组CD8^(+)(30.61±5.24)%、病毒组(29.64±5.18)%均显著高于对照组,差异有统计学意义(F=9.185,P<0.05),细菌组与病毒组比较,差异无统计学意义(P>0.05)。结论白细胞计数、超敏C反应蛋白和T细胞亚群水平检测在急性上呼吸道感染合并发热惊厥中具有较高的诊断价值,且白细胞计数和超敏C反应蛋白的检测有助于鉴别诊断急性上呼吸道感染的病原体类型,能够为患儿临床治疗提供指导依据。

Objective To study and analyze the clinical value of white blood cell count,high-sensitivity C-reactive protein and T cell subsets in the diagnosis of acute upper respiratory tract infection complicated with febrile seizures in children.Methods A total of 70 children with acute upper respiratory tract infection complicated with febrile con⁃vulsion admitted to Yixing Hospital Affiliated to Jiangsu University from January 2020 to April 2021 were selected as the research objects.According to the pathogen type,they were divided into bacterial group and virus group,35 cases in each group.At the same time,35 healthy children who underwent physical examination were selected as the control group.White blood cell count,high sensitivity C-reactive protein and T cell subsets were detected and compared among the three groups.Results The white blood cell count was(19.15±3.68)×10^(9)/L in bacterial group,(4.58±1.22)×10^(9)/L in virus group,bacterial group>control group>virus group,the difference was statistically significant(F=383.968,P<0.05).The high sensitivity C-reactive protein of bacterial group was(17.52±3.16)mg/L,and that of virus group was(3.13±0.58)mg/L,bacterial group>virus group>control group,the difference was statistically significant(F=756.274,P<0.05).CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in bacterial group were(41.46±7.73)%,(29.82±5.62)%,(0.97±0.35),and(42.18±7.25)%,(30.31±5.81)%,(1.02±0.36)in virus group,respectively,which were significantly lower than those in control group,the difference was statistically significant(F=38.738,20.514,18.221,P<0.05),and there was no significant difference between the bacteria group and the virus group(P>0.05).CD8^(+)(30.61±5.24)%in bacterial group and(29.64±5.18)%in virus group were significantly higher than those in control group,the difference was sta⁃tistically significant(F=9.185,P<0.05),and there was no statistically significant difference between the bacteria group and the virus group(P>0.05).Conclusion The detection of white blood cell count,high-sensitivity C-reactive protein and T-cell subsets has high diagnostic value in acute upper respiratory tract infection complicated with febrile convul⁃sion.In addition,the detection of white blood cell count and high-sensitivity C-reactive protein can help to differenti⁃ate and diagnose the pathogen types of acute upper respiratory tract infection,and can provide guidance for clinical treatment of children.