血清免疫球蛋白检验在肝衰竭患者的诊断价值

Diagnostic Value of Serum Immunoglobulin Test in Patients with Liver Failure

目的探究血清免疫球蛋白检验在肝衰竭患者的诊断价值。方法选取2019年2月—2021年8月在江苏省南京市高淳人民医院行肝衰竭患者治疗的110例患者为研究对象(观察组),另选取同期体检健康者110名为对照组。两组均接受血清免疫球蛋白检验,分析两组血清免疫球蛋白情况及观察组不同发病时期免疫球蛋白水平情况。结果观察组3项血清免疫球蛋白指标水平IgA(2.61±0.97)g/mL、IgG(17.23±1.35)g/mL及IgM(2.97±0.87)g/mL,均高于对照组[(1.15±1.02)g/mL、(10.78±1.02)g/mL、(1.40±0.41)g/mL],差异有统计学意义(t=-10.879、-39.981、-17.121,P<0.05);且观察组晚期患者的3项免疫球蛋白指标均高于早期及中期,差异有统计学意义(P<0.05)。结论血清免疫球蛋白检验不仅能作为肝衰竭患者的重要诊断标准,还能有效判断患者的病情严重程度,更有利于患者预后。

Objective To explore the diagnostic value of serum immunoglobulin test in patients with liver failure.Methods A total of 110 patients with liver failure treated in Nanjing Gaochun People's Hospital of Jiangsu Province from February 2019 to August 2021 were selected as object of study(observation group),and 110 healthy people who underwent physical examination during the same period were selected as the control group.Serum immunoglobulin test was performed in both groups,and the serum immunoglobulin levels in the two groups and the observation group at different onset periods were analyzed.Results The three serum immunoglobulin indexes of IgA(2.61±0.97)g/mL,IgG(17.23±1.35)g/mL and IgM(2.97±0.87)g/mL in the observation group were higher than those in the control group[(1.15±1.02)g/mL,(10.78±1.02)g/mL,(1.40±0.41)g/mL],and the difference was statistically significant(t=-10.879,-39.981,-17.121,P<0.05);and the three immunoglobulin indexes in the late-stage patients in the observation group were higher than those in the early-stage and mid-stage,and the difference was statistically significant(P<0.05).Conclusion Serum immunoglobulin test can not only be used as an important diagnostic standard for patients with liver failure,but also can effectively judge the severity of the patient's disease,which is more conducive to the progno⁃sis of the patient.