针刺联合补肾活血方治疗肾虚血瘀型排卵障碍性不孕的临床研究

Clinical study on acupuncture combined with Bushen Huoxue Prescription in the treatment of ovulatory dysfunction infertility of kidney deficiency and blood stasis type

目的 观察针刺联合补肾活血方治疗肾虚血瘀型排卵障碍性不孕的临床疗效。方法 将90例肾虚血瘀型排卵功能障碍性不孕症患者随机分为针药组、中药组和对照组,每组30例。对照组仅给予促排卵西药治疗,中药组在对照组基础上加用中药治疗,针刺组在中药组基础上加针刺治疗,疗程为1~3个月经周期。疗程结束后,比较各组尿促性腺激素(HMG)的周期使用量,排卵、妊娠及卵巢过度刺激综合征(OHSS)、黄素化卵泡不破裂综合征(LUFS)、无反应周期发生情况。结果(1)针药组HMG周期使用量较其他两组明显减少,中药组介于其他两组之间,各组间差异均有统计学意义(P<0.05);(2)针药组及中药组的排卵周期数均优于对照组(P<0.05),中药组与针药组之间差异无统计学意义(P>0.05);(3)针药组妊娠周期数明显优于对照组(P<0.05),与中药组比较差异无统计学意义,中药组与对照组比较差异无统计学意义(P>0.05);(4)各组OHSS、LUFS发生情况差异无统计学意义(P>0.05);(5)针药组的无反应周期明显少于对照组(P<0.05),与中药组比较差异无统计学意义(P>0.05),中药组与对照组比较差异无统计学意义(P>0.05)。结论 针刺联合补肾活血方治疗肾虚血瘀型排卵功能障碍性不孕症,可明显减少HMG周期使用量,增加卵泡发育周期,减少无排卵周期,提高周期妊娠率。

Objective To observe the effects of acupuncture combined with Bushen Huoxue Prescription in the treatment of ovulatory dysfunction infertility of kidney deficiency and blood stasis type.Methods A total of 90 ovulatory infertility patients were randomly divided into acupuncturemedication group,traditional Chinese medicine(TCM)group and control group,with 30 cases in each group.The control group was only treated with ovulation induction,the TCM group was treated with TCM combined with ovulation induction,and the acupuncture-medication group was treated with acupuncture in addition. Each group was treated with 1~3 menstrual cycles. The occurrence of ovulation,pregnancy and ovarian hyperstimulation(OHSS),luteinization(LUFS) and unresponsive cycle were compared among groups.Results (1) Compared with the other two groups,the acupuncture group used less HMG periodic,while the TCM group was between the other two groups,and the difference among those was statistically significant(P<0.05).(2)Cycle ovulation rate of both traditional Chinese medicine group and acupuncture-medication group were significantly higher than that of the control group(P<0.05),but there was no significant difference between the traditional Chinese group and the acupuncture-medication group(P>0.05).(3)The pregnancy cycles of acupuncture-medication group were significantly better than those of the control group(P<0.05),but there was no significant difference between the acupuncture-medication group and the TCM group(P>0.05),and no significant difference between the TCM group and the control group(P>0.05).(4)There was no significant difference in the incidence of OHSS cycle and LUFS cycle among the three groups(P>0.05).(5)The anovulatory cycles of the acupuncture group were less than the control group(P<0.05).There was no significant difference between acupuncture-medication group and the TCM group(P>0.05),also between the TCM group and the control group(P>0.05).Conclusion Acupuncture-medication group can significantly reduce the use of HMG cycle, increase the follicular development cycle, reduce anovulatory cycle and improve the pregnancy cycle rate.