重组人红细胞生成素-β注射液对糖尿病肾病腹膜透析患者炎症因子水平及氧化应激水平的影响

Effect of recombinant human erythropoietinβinjection on inflammatory factor levels and oxidative stress levels in diabetic nephropathy patients undergoing peritoneal dialysis

目的探讨重组人红细胞生成素-β注射液对糖尿病肾病腹膜透析患者炎症因子及氧化应激水平的影响。方法回顾性选取2020年2月至2021年2月潜江市中心医院肾内科糖尿病肾病患者60例,依据治疗方法不同分为腹膜透析治疗组和腹膜透析治疗基础上使用重组人红细胞生成素-β注射液治疗组(红细胞生成素组),每组各30例,统计分析两组炎症因子水平、氧化应激水平、贫血状况、肾功能、治疗满意度。结果红细胞生成素组患者的肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、白介素-6(IL-6)水平均低于腹膜透析治疗组,差异有统计学意义(P<0.05)。红细胞生成素组患者的谷胱甘肽过氧化物酶(GSH-Px)、总超氧化物歧化酶(T-SOD)水平均高于腹膜透析治疗组,丙二醛(MDA)水平低于腹膜透析治疗组,差异有统计学意义(P<0.05)。红细胞生成素组患者的铁离子(Fe^(2+))、红细胞压积(Hct)、血红蛋白(Hb)水平均高于腹膜透析治疗组,差异有统计学意义(P<0.05)。红细胞生成素组患者的血肌酐(Scr)、尿白蛋白排泄率(UAER)均低于腹膜透析治疗组,差异有统计学意义(P<0.05)。红细胞生成素组患者的治疗满意度为93.33%(28/30),高于腹膜透析治疗组63.33%(19/30),差异有统计学意义(P<0.05)。结论糖尿病肾病腹膜透析治疗基础上重组人红细胞生成素-β注射液治疗较腹膜透析治疗能有效改善患者炎症因子及氧化应激水平。

Objective To explore the effect of recombinant human erythropoietinβinjection on inflammatory factor levels and oxidative stress levels in diabetic nephropathy patients undergoing peritoneal dialysis.Methods A total of 60 patients with diabetic nephropathy admitted to the Department of Nephrology of Qianjiang Central Hospital from February 2020 to February 2021 were retrospectively selected and divided into the peritoneal dialysis treatment group and the erythropoietin group(the erythropoietin group received recombinant human erythropoietinβinjection on the basis of peritoneal dialysis treatment)according to the treatment method,with 30 patients in each group.The inflammatory factor levels,oxidative stress levels,anemia status,renal function and treatment satisfaction were statistically analyzed between the two groups.Results The levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)in the erythropoietin group were significantly lower than those in the peritoneal dialysis treatment group,with statistically significant differences(P<0.05).The levels of glutathione peroxidase(GSH-Px)and total superoxide dismutase(T-SOD)in the erythropoietin group were higher than those in the peritoneal dialysis treatment group,with statistically significant differences(P<0.05).The malondialdehyde(MDA)level in the erythropoietin group was lower than that in the peritoneal dialysis treatment group,with statistically significant difference(P<0.05).The levels of ferrous ions(Fe^(2+)),hematocrit(Hct)and hemoglobin(Hb)in the erythropoietin group were higher than those in the peritoneal dialysis treatment group,with statistically significant differences(P<0.05).The serum creatinine(Scr)and urinary albumin excretion rate(UAER)of the erythropoietin group were lower than those of the peritoneal dialysis treatment group,with statistically significant differences(P<0.05).The treatment satisfaction in the erythropoietin group(93.33%,28/30)was higher than that in the peritoneal dialysis treatment group(63.33%,19/30),with statistically significant differences(P<0.05).Conclusion Compared with peritoneal dialysis treatment,recombinant human erythropoietinβinjection on the basis of peritoneal dialysis treatment is more effective in improving the inflammatory factor levels and oxidative stress levels in diabetic nephropathy patients.