甘麦大枣汤联合原络针刺治疗更年期失眠症女性患者的疗效及对血清神经递质水平的影响

The effect of the Ganmai Dazao decoction plus Yuanluo acupuncture on female menopausal insomnia and its influence on serum neurotransmitter levels

目的:探讨甘麦大枣汤联合原络针刺法治疗更年期失眠症女性患者的疗效及对血清神经递质水平的影响。方法:选取2019年1月-2020年6月于北京市昌平区中西医结合医院分院就诊的98例更年期失眠症女性患者作为研究对象,按随机数表法分为对照组和观察组,各49例。对照组予以艾司唑仑片治疗,观察组予以甘麦大枣汤联合原络针刺法治疗,两组均持续治疗1个月。对比两组治疗后的临床疗效,治疗前后的匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评分,血清雌二醇(Estradiol,E)、孕酮(Progesterone,P)、促卵泡生成素(Follicle Stimulating Hormone,FSH)、促黄体生成素(Luteinizing Hormone,LH)水平及血清5-羟色胺(5-hydroxytryptamine,5-HT)、γ-氨基丁酸(γ-aminobutyric Acid,GABA)、去甲肾上腺素(Norepinephrine,NE)、神经肽Y(Neuropeptide Y,NPY)、P物质(P Substance,SP)水平。结果:观察组的总有效率高于对照组(P<0.05)。治疗后两组PSQI各指数评分及总分均较治疗前下降,且观察组均低于对照组(P<0.05)。两组血清E、P水平均较治疗前上升,且观察组均高于对照组,两组血清FSH、LH水平均较治疗前下降,且观察组均低于对照组(P<0.05)。两组血清5-HT、GABA、NPY水平均较治疗前上升,且观察组均高于对照组,两组血清NE、SP水平均较治疗前下降,且观察组均低于对照组(P<0.05)。结论:甘麦大枣汤联合原络针刺法治疗可有效改善更年期失眠症女性患者的失眠症状,其作用机制可能与调节患者体内的血清性激素水平及神经递质有关。

Objective:To explore the curative effect of the Ganmai Dazao decoction(甘麦大枣汤)plus Yuanluo(原络)acupuncture on female menopausal insomnia and its influence on serum neurotransmitter levels.Methods:A total of 98 cases from January 2019 to June 2020 were selected as the research subjects and divided into the control group(49 cases)and the observation group(49 cases)according to the random number table method.The control group was treated with estazolam tablets,and the observation group was treated with the Ganmai Dazao decoction plus Yuanluo acupuncture.Both groups were treated continuously for 1 month.Results:The total efficiency in the observation group was higher than the control group(P<0.05).After treatment,the PSQI all index scores and total scores in the two groups were lower than before treatment,and in the observation group was lower than the control group(P<0.05).The serum E2 and P levels in the two groups were higher than before treatment,and thase in the observation group was higher than the control group.The serum FSH and LH levels in the two groups were lower than before treatment,and thase in the observation group was lower than the control group(P<0.05).The levels of serum 5-HT,GABA,and NPY in the two groups were higher than before treatment,and thase in the observation group were higher than the control group.The serum NE and SP levels in the two groups were lower than before treatment,and thase in the observation group were lower than the control group(P<0.05).Conclusion:The Ganmai Dazao decoction plus Yuanluo acupuncture can effectively relieve insomnia symptoms of female menopausal insomnia patients,and its action mechanism may be related to the regulation of serum sex hormone and neurotransmitter levels in patients.