维生素D与糖尿病足相关性研究进展

Research progress on the relationship between vitamin D and diabetic foot

维生素D缺乏已悄然成为一种流行病,越来越多的临床研究发现糖尿病足患者更容易出现维生素D缺乏,且维生素D缺乏可能导致糖尿病足不易愈合。基础研究发现,补充维生素D可通过增强抗菌肽的表达、改善金属基质蛋白酶、调节免疫及炎性因子等多途径促进糖尿病足溃疡的愈合。基于“肾藏精”的中医理论,维生素D或许是补肾法治疗糖尿病足的潜在机制。因此,维生素D可能是治疗糖尿病足的重要机制之一。

Vitamin D deficiency has become a quiet epidemic.More and more clinical studies have found that diabetic foot are more prone to vitamin D deficiency,and vitamin D deficiency may cause diabetic foot ulcer to be difficult healing.Basic research has found that vitamin D supplementation can promote the healing of diabetic foot ulcers by enhancing the expression of antimicrobial peptides,improving metal matrix proteases,regulating immunity and inflammatory factors.Based on the traditional Chinese medicine theory of“kidney collection essence”,vitamin D may be a potential mechanism for the treatment of diabetic foot.Therefore,vitamin D supplementation may be an important mechanisms for the treatment of diabetic foot.