摘要
慢性偏头痛是世界上最普遍和最易致残的神经源性炎症性病症之一,严重影响患者生命质量,但其机制至今仍未十分明确。最新研究提示在中枢炎症疾病中存在“星形胶质细胞-小胶质细胞”串扰,是阐释发病和治疗机制的新靶点。前期机制研究初步发现了针刺治疗慢性偏头痛与其调控星形胶质细胞与小胶质细胞关系密切。现从最新的神经炎症性疾病研究前沿“星形胶质细胞-小胶质细胞”串扰出发,探讨将其引入针刺治疗慢性偏头痛机制研究中的可能性,以期为针刺慢性偏头痛提供新的科学思路。
Chronic migraine is one of the most prevalent and disabling neurogenic inflammatory diseases in the world, severely impacting the quality of life of patients.However, its mechanism is still unclear.Recent studies suggest that the astrocyte-microglia crosstalk is observed in central inflammatory diseases, which is a new target for the elucidation of the pathogenesis and therapeutic mechanisms.Previous studies initially found that the mechanism of acupuncture in the treatment of chronic migraine was closely related to its regulation of astrocytes and microglia.Therefore, based on astrocyte-microglia crosstalk, the latest research frontier of neuroinflammatory diseases, this paper explored the possibility of introducing it into the mechanism study of acupuncture in the treatment of chronic migraine, thereby providing new scientific ideas for the treatment of chronic migraine with acupuncture.
作者
孙铭声
周梦荻
刘一
刘路
倪夕秀
徐韬
蔡定均
赵凌
SUN Mingsheng;ZHOU Mengdi;LIU Yi;LIU Lu;NI Xixiu;XU Tao;CAI Dingjun;ZHAO Ling(School of Acupuncture and Massage,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《世界中医药》
CAS
2022年第17期2394-2399,共6页
World Chinese Medicine
基金
国家重点研发计划项目(2019YFC1709700)——“宣阳解郁,通络止痛”法防治偏头痛的循证评价及机制研究
国家自然科学基金面上项目(81973962)——基于脑-肠轴的慢性偏头痛针刺疗效差异机制及适宜人群筛选的影像组学研究
国家自然科学基金青年科学基金项目(82004486)——基于肠道菌群介导SCFAs调控小胶质细胞活化的循经取穴针刺治疗偏头痛效应机制研究
中国博士后科学基金面上项目(2020M683643XB)——基于肠道菌群介导针刺治疗慢性偏头痛的镇痛机制研究。
