加味射干麻黄汤联合孟鲁司特钠对支气管哮喘患者肺功能的影响

Effect of Supplemented Shegan Mahuang Decoction Combined with Montelukast Sodium on Lung Function in Patients with Bronchial Asthma

目的:分析加味射干麻黄汤联合孟鲁司特钠对支气管哮喘患者肺功能的影响。方法:选取2019年1月至2021年6月芜湖市中医院呼吸科收治的支气管哮喘患者100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例。对照组患者给予孟鲁司特钠治疗,观察组患者采用加味射干麻黄汤联合孟鲁司特钠治疗,比较2组患者治疗前后的临床疗效、肺功能指标、白细胞介素-6(IL-6)水平、嗜酸性粒细胞(EOS)水平、症状改善时间、中医证候积分、生命质量,以及不良反应发生情况。结果:治疗后,观察组的总有效率明显高于对照组(P<0.05),不良反应总发生率略高于对照组(P>0.05)。观察组的第1秒用力呼气容积(FEV)、第1秒用力呼气容积/用力肺活量(FEV/FVC)水平明显高于对照组(P<0.05)。观察组的IL-6及EOS水平与咳嗽、胸闷、气短、喘息及呼吸困难改善时间与中医证候积分、Marks哮喘生命质量问卷(Marks-AQLQ)评分明显低于对照组(均P<0.05)。结论:加味射干麻黄汤联合孟鲁司特钠可有效改善支气管哮喘患者的肺功能,降低炎症反应,并缓解临床症状,提高生命质量,疗效明显,且安全性及临床应用价值均较高。

Objective:To analyze the effect of Supplemented Shegan Mahuang Decoction combined with montelukast sodium on lung function of patients with bronchial asthma.Methods:A total of 100 patients with bronchial asthma who were treated in the Department of Respiratory Medicine, Wuhu Hospital of Traditional Chinese Medicine from January 2019 to June 2021 were selected and randomized into the control group(n=50) and research group(n=50).The control group was treated with montelukast sodium, and the research group with montelukast sodium and Supplemented Shegan Mahuang Decoction.The clinical efficacy, lung function indexes, levels of interleukin-6(IL-6) and eosinophil(EOS),symptom alleviation time, TCM syndrome score, quality of life, and incidence of adverse reactions were compared between the two groups.Results:After treatment, the total effective rate of the research group was higher than that of control group(P<0.05),and the total incidence of adverse reactions was slightly higher than that in control group(P>0.05).The forced expiratory volume in one second(FEV1) and the forced expiratory volume in one second/forced vital capacity(FEV1/FVC) in the research group were higher than those in control group(P<0.05).The levels of IL-6 and EOS,alleviation time of cough, chest tightness, shortness of breath, wheezing, and dyspnea, TCM syndrome score, and Marks-AQLQ score in the research group were lower than those in the control group(P<0.05).Conclusion:The combination of Supplemented Shegan Mahuang Decoction and montelukast sodium can effectively improve the lung function and quality of life of patients with bronchial asthma, reduce inflammation, and alleviate the clinical symptoms, with obvious curative effect.The combination is safe and worthy of further application.